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Bone Mineral Density in Women with Polycystic Ovary Syndrome

McCleary, Lara (2008) Bone Mineral Density in Women with Polycystic Ovary Syndrome. Master's Thesis, University of Pittsburgh. (Unpublished)

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Background: Polycystic ovary syndrome (PCOS) is a common complex hormonal disorder. Many PCOS symptoms may have implications on bone mineral density (BMD). One way to analyze BMD is quantitated computed tomography (QCT), which may have advantages over other BMD analysis methods. The study analyzed descriptive characteristics of a group of PCOS cases and controls; considered the determinants of BMD (as measured by QCT) from the literature in PCOS cases and controls; and adjusted for these variables via multivariate logistic regression to determine if PCOS case status is an independent predictor of lumbar BMD after controlling for these factors. Methods: The study used women from the third implementation of the University of Pittsburgh Cardiovascular Health and Risk Management study (CHARM III). Descriptive information was gathered by survey and clinical visits and blood samples were taken to measure hormones and other biological factors. Lumbar BMD was measured by QCT in a subset of women. Student's T-Test, the Mann-Whitney U-Test and X2 tests were used to evaluate descriptive characteristics of PCOS cases and controls. BMD measures between PCOS case and controls were compared using Student's T-test. Lumbar BMD comparisons between PCOS cases and controls were also stratified by factors determined from the literature to affect BMD, including age, ethnicity, menstrual period status, BMI, and menstrual history. Correlations of BMD with hormones in cases and controls were considered. Multivariate linear regression models were used to assess the effect of PCOS case-control status on lumbar BMD after controlling for these factors associated with BMD. Results: There was no significant BMD difference between PCOS cases and controls for any univariate comparisons, nor for any multivariate adjusted compositions. Conclusion: The deleterious effects of middle age and approaching menopause and the protective effects of heavy BMI in controls may mediate some protective effects of PCOS case status on BMD in this group. Statement of Public Health Significance: The current study is one of only a few to use QCT to measure BMD in women with PCOS. Results from this study can serve as the basis of comparison for other studies that use QCT methods to assess BMD.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
McCleary,; lmccleary@chemadvisor.comLBM1
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairTalbott, Evelyn Oeot1@pitt.eduEOT1
Committee MemberCauley, Janejcauley@edc.pitt.eduJCAULEY
Committee MemberWilson, Johnwilson@nsabp.pitt.eduJWW
Date: 31 January 2008
Date Type: Completion
Defense Date: 6 December 2007
Approval Date: 31 January 2008
Submission Date: 6 December 2007
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Epidemiology
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: BMD; bone mineral density; PCOS; Polycystic Ovary Syndrome; QCT; quantitated computed tomography
Other ID:, etd-12062007-134312
Date Deposited: 10 Nov 2011 20:08
Last Modified: 15 Nov 2016 13:53


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