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Bryan, Charlene Joanne (2007) THE ASSOCIATION OF DIABETES MELLITUS WITH RESPONSE TO DEPRESSION TREATMENT. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Major Depression is a serious mental illness which if left untreated can lead to severe mental and physical debilitation. Major depression often occurs concurrently with many, serious, medical co-morbidities, e.g. diabetes mellitus. Primary care physicians now have to treat more medically complex patients due to the increasing incidence of diabetes mellitus and the increase of screening for major depression in the primary clinic settings. There are little data available about the impact of diabetes mellitus on depression treatment and this report will provide some of this data to the treating clinician. The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) was the largest study of major depression in the U.S. to date, with an enrollment of 4041. STAR*D offered a unique opportunity to examine the impact of diabetes on depression and antidepressant treatment. This report focused on the presenting characteristics and treatment outcomes of diabetics from the first STAR*D treatment level.At study entry, diabetics differed on key socio-demographic variables, e.g. race/ethnicity and reported lower physical functioning at baseline across measures of quality of life and depression severity. Diabetics had poorer outcomes, although after adjustment for potential confounders, there was no statistically significant difference in these outcomes. Diabetics received similar treatment regimens as non-diabetic participants and reported fewer side effects at the conclusion of the first treatment level with citalopram. Diabetics also reported a lesser overall impact of side effects than non-diabetics, although these results were limited by a lack of available baseline side effect data for comparison.These findings are of some importance to clinicians. The lack of an independent association of diabetes with major depression treatment response after adjustment for confounding factors implies that clinicians can treat diabetic patients similarly to those without diabetes mellitus for major depression. This is of some public health significance as untreated or poorly treated major depression adversely impacts diabetes disease management, which in turn can lead to the development of life-threatening diabetes complications. The importance of developing MDD treatment modalities that result in sustained remission for individuals with major depression and diabetes mellitus cannot be over-stated.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Bryan, Charlene
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairWisniewski, Stephen Rwisniew@edc.pitt.eduSTEVEWIS
Committee MemberBrooks, Maria Moribrooks@edc.pitt.eduMBROOKS
Committee MemberThase, Michael E
Committee MemberSonger, Thomas Jtjs@pitt.eduTJS
Date: 15 February 2007
Date Type: Completion
Defense Date: 30 May 2006
Approval Date: 15 February 2007
Submission Date: 8 December 2006
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Epidemiology
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: antidepressants; citalopram; major depressive disorder
Other ID:, etd-12082006-175048
Date Deposited: 10 Nov 2011 20:09
Last Modified: 15 Nov 2016 13:53


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