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Cellular specialization of synaptic integration in a mammalian sympathetic ganglion

Li, Chen (2007) Cellular specialization of synaptic integration in a mammalian sympathetic ganglion. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Sympathetic ganglia are widely viewed as simply relays that are essential to convey neural activity from spinal preganglionic neurons to distinct peripheral targets. However, recent studies indicate that synaptic integration in sympathetic ganglia is more complex than that of a simple excitatory relay. It is proposed that synaptic organization of each functional subset of sympathetic ganglion cells is specialized to generate a unique synaptic gain function, thereby allowing for differential control of specific target modalities. This dissertation describes cellular specialization of some critical determinants of synaptic gain in rat superior cervical ganglion (SCG) neurons. The work was first focused on identifying presynaptic stimulus threshold and NPY immunoreactivity as neuronal classification criteria of secretomotor, pilomotor and vasoconstrictor cells. The results here show that these three functional phenotypes of neurons are indistinguishable in terms of synaptic convergence. Furthermore, norepinephrine (NE) causes different modulatory effects upon pre and postsynaptic ¦Á2-adrenergic receptors in these cell types. Collectively, this work characterizes cellular specialization of synaptic convergence and NE neuromodulatory mechanism that are involved in synaptic integration in the rat SCG.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Li, Chenchl2603@pitt.eduCHL2603
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairDavis, Brian Mbmd1@pitt.eduBMD1
Committee CoChairHorn, John Pjph@pitt.eduJPH
Committee MemberWeinreich,
Committee MemberAizenman, Eliasredox@pitt.eduREDOX
Committee MemberTorres, Gonzalo Egtorres@pitt.eduGTORRES
Committee MemberRubin, Jonathan Erubin@math.pitt.eduJONRUBIN
Date: 17 December 2007
Date Type: Completion
Defense Date: 7 December 2007
Approval Date: 17 December 2007
Submission Date: 16 December 2007
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Neurobiology
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: gain; blood pressure; N-type calcium channel
Other ID:, etd-12162007-144326
Date Deposited: 10 Nov 2011 20:11
Last Modified: 15 Nov 2016 13:54


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