Henderson, Wendy Ann
(2008)
TESTING A MODEL OF HEALTH-RELATED QUALITY OF LIFE IN PERSONS WITH HIV AND LIVER DISEASE.
Doctoral Dissertation, University of Pittsburgh.
(Unpublished)
Abstract
Persons living with human immunodeficiency virus (HIV) are living longer and therefore are more likely to suffer significant morbidity due to potentially treatable liver diseases. Liver diseases alone have been shown to have a significant negative effect on one's health-related quality of life (HRQOL). Clinical evidence suggests that persons living with HIV and liver disease, a growing number of individuals, may have a poorer HRQOL than persons living with HIV who do not have liver disease. Thus, this study examined the multiple components of HRQOL by testing Wilson and Cleary's model in persons with HIV and in persons living with HIV and liver disease using structural equation modeling. This secondary analysis used de-identified baseline and medical record review data from a parent study testing interventions to improve medication adherence in persons living with HIV (R01 NR04749). The Wilson and Cleary model components include: biological/physiological factors (HIV viral load, CD4 counts), symptom status (Beck Depression Inventory II, Medical Outcomes Study HIV Health Survey [MOS-HIV] mental function), functional status (missed appointments, MOS-HIV physical function), general health perceptions (Perceived burden visual analogue scale, MOS-HIV health transition), and overall QOL (Satisfaction with Life Scale, MOS-HIV overall QOL). Characteristics of the individual and environment were also explored. The Wilson and Cleary (1995) model was found to be useful in linking clinical indicators to patient-related outcomes. The findings provide the foundation for development and future testing of a targeted bio-behavioral nursing intervention to improve HRQOL in persons living with HIV and liver disease.
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| Item Type: |
University of Pittsburgh ETD
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| Status: |
Unpublished |
| Creators/Authors: |
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| ETD Committee: |
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| Date: |
9 January 2008 |
| Date Type: |
Completion |
| Defense Date: |
30 August 2007 |
| Approval Date: |
9 January 2008 |
| Submission Date: |
28 December 2007 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
School of Nursing > Nursing |
| Degree: |
PhD - Doctor of Philosophy |
| Thesis Type: |
Doctoral Dissertation |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
biologic factors; health-related quality of life; HIV; liver disease; model testing; nursing; patient related outcomes; structural equation modeling |
| Other ID: |
http://etd.library.pitt.edu/ETD/available/etd-12282007-123622/, etd-12282007-123622 |
| Date Deposited: |
10 Nov 2011 20:11 |
| Last Modified: |
15 Nov 2016 13:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/10458 |
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