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Estimating the Survival Distribution for Right-Censored Data with Delayed Ascertainment

Kim, Eun-Jin (2012) Estimating the Survival Distribution for Right-Censored Data with Delayed Ascertainment. Master's Thesis, University of Pittsburgh. (Unpublished)

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Abstract

In many clinical trials, patients are not followed continuously. This means their vital status may not be immediately recorded. In such cases, the results from the Kaplan-Meier estimator or the log rank test, popular methods used for survival analysis, may be biased or inconsistent. Hu and Tsiatis first produced a new estimator to estimate survival distribution for right-censored data with delayed ascertainment, Van der Laan and Hubbard modified their estimator. We investigate each of these proposed estimators and their properties. Using simulations, we compare these new estimators to each other and to the Kaplan-Meier estimator using different sample sizes, different failure rates, and different maximum delay times. The public health importance of this thesis is that we can partially alleviate the problem caused by delayed ascertainment in the analysis of right-censored time to event data by choosing the most accurate and consistent estimator that accounts for the delayed ascertainment. The reduction of bias in analyses of public health data ensures that such studies are reliable so that proper inference can be made and hence, potential public health policy can be based on an accurate decision making process.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Kim, Eun-Jinonly4jin@gmail.com
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Thesis AdvisorAnderson, Stewartandersons@nsabp.pitt.eduSJA
Committee MemberJeong, Jong-Hyeon Jeong@nsabp.pitt.eduJJEONG
Committee MemberBrooks, Mariambrooks@pitt.eduMBROOKS
Date: 30 January 2012
Date Type: Completion
Defense Date: 7 December 2011
Approval Date: 30 January 2012
Submission Date: 29 November 2011
Access Restriction: 1 year -- Restrict access to University of Pittsburgh for a period of 1 year.
Number of Pages: 34
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Biostatistics
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Survival analysis, Right censored, Ascertainment
Date Deposited: 30 Jan 2012 18:45
Last Modified: 15 Nov 2016 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/10572

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