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ASSOCIATION OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 AND C-REACTIVE PROTEIN WITH MODERATE-TO-VIGOROUS PHYSICAL ACTIVITY IN MIDDLE-AGED WOMEN

Rice, David (2012) ASSOCIATION OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 AND C-REACTIVE PROTEIN WITH MODERATE-TO-VIGOROUS PHYSICAL ACTIVITY IN MIDDLE-AGED WOMEN. Doctoral Dissertation, University of Pittsburgh.

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Abstract

Coronary heart disease (CHD) is an inflammatory process that is the most common form of cardiovascular diseas(CVD). People who are habitually physically active have comparatively lower levels of certain inflammatory biomarkers. C-reactive protein (CRP) is considered the “gold standard” to assess the relation between physical activity and inflammation. Lipoprotein- associated phospholipase A2 (Lp-PLA2) is an inflammatory marker that has been shown to be associated with CHD. However, little is known about what association Lp-PLA2 might have with habitual physical activity.
Purpose: The current investigation examined the association between Lp-PLA2 and moderate-to-vigorous physical activity (MVPA). A secondary purpose was to examine the association between CRP and MVPA. Finally, this investigation examined the association between Lp-PLA2 and CRP.
Methods: This investigation was a secondary analysis of data that were previously collected as part of the Epidemiologic Study of Health Risk in Women (ESTHER). Seventy-five females (50.2 ± 10 yrs.) were selected for the current investigation and were assigned to either the ACTIVE or INACTIVE group. The ACTIVE group was comprised of those who reported the highest levels of MVPA (≥ 8.93 hours/week) during the previous 12 months. The INACTIVE group comprised participants who reported no MVPA over the previous 12 months. Blood samples from each participant were analyzed for levels of Lp-PLA2 mass, Lp-PLA2 activity and CRP.

Results: No significant differences were found between the ACTIVE and INACTIVE groups for mean values of either Lp-PLA2 mass (ACTIVE= 226.4 ± 48.1 ng/ml, INACTIVE=217.6 ± 50.4 ng/ml, p = 0.44) or Lp-PLA2 activity (ACTIVE=133.3 ± 26.4 nmol/min/ml, INACTIVE=136.5 ±
30.5 nmol/min/ml, p = 0.63). CRP values were significantly (p = 0.02) lower in the ACTIVE group as compared to the INACTIVE group. It was found that neither Lp-PLA2 mass nor Lp- PLA2 activity were significantly correlated with CRP values.
Conclusions: Based on the current findings, it can be concluded that Lp-PLA2 is not associated with MVPA in heterosexual, middle-aged women. Other inflammatory markers that have been found to be associated both with CHD and PA, such as CRP, IL-6, and TNF- α, should continue to be examined.


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Details

Item Type: University of Pittsburgh ETD
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Rice, Daviddrice27@charter.net
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairRobertson, Robert
Committee MemberNagle, Elizabeth
Committee MemberDanielson, Michelle
Committee MemberOrchard , Trevor
Date: 11 January 2012
Date Type: Publication
Defense Date: 26 August 2011
Approval Date: 11 January 2012
Submission Date: 3 January 2012
Release Date: 11 January 2012
Access Restriction: 1 year -- Restrict access to University of Pittsburgh for a period of 1 year.
Number of Pages: 80
Institution: University of Pittsburgh
Schools and Programs: School of Education > Health and Physical Activity
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: Inflammation
Date Deposited: 11 Jan 2012 20:56
Last Modified: 15 Nov 2016 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/10777

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