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Augmentation of cardiac function by elevation of intrathoracic pressure

Pinsky, MR and Summer, WR and Wise, RA and Permutt, S and Bromberger-Barnea, B (1983) Augmentation of cardiac function by elevation of intrathoracic pressure. Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, 54 (4). 950 - 955. ISSN 0161-7567

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We studied the cardiovascular effects of increasing intrathoracic pressure in an acute pentobarbital-anesthetized canine model of acute ventricular failure induced by large doses of propranolol. Left ventricular (LV) function curves were generated by volume loading from LV filling pressures of 5-20 Torr. The animals were ventilated by using intermittent positive-pressure ventilation with large tidal volumes (30 ml/kg). Chest and abdominal pneumatic binders were used to increase intrathoracic pressure. When compared with the control state, acute ventricular failure was associated with a decrease in the slope of the LV function curves (P < 0.01). After binding the increase in intrathoracic pressure (1.1 ± 1.6 to 12.1 ± 2.4 Torr, P < 0.01) was associated with an improvement in both right ventricular and LV function. Our study demonstrates that in this model of acute ventricular failure, increasing intrathoracic pressure improves cardiac function. We postulate that this observed improvement with increased intrathoracic pressure is due to reduced LV wall stress in a manner analogous to that seen with arterial vasodilator therapy in congestive heart failure.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Summer, WR
Wise, RA
Permutt, S
Bromberger-Barnea, B
Date: 1 January 1983
Date Type: Publication
Journal or Publication Title: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume: 54
Number: 4
Page Range: 950 - 955
DOI or Unique Handle: 10.1152/jappl.1983.54.4.950
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 0161-7567
Date Deposited: 24 Feb 2012 15:29
Last Modified: 22 Jun 2020 13:55


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