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Effect of positive end-expiratory pressure on hypoxic pulmonary vasoconstriction in the dog.

Domino, KB and Pinsky, MR (1990) Effect of positive end-expiratory pressure on hypoxic pulmonary vasoconstriction in the dog. Am J Physiol, 259 (3 Pt 2). H697 - H705. ISSN 0002-9513

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Abstract

We studied the effects of uni- and bilateral positive end-expiratory pressure (PEEP) on pulmonary artery pressure-flow (Ppa/Q) relationships during unilateral hypoxia in anesthetized dogs. A bronchial divider was inserted, the right lung was ventilated with 100% O2, and the left lung was ventilated with either 100% O2 (hyperoxia) or a hypoxic gas mixture (hypoxia). Left lung blood flow (QL) and aortic flow (QT) were measured by electromagnetic flow probes. Simultaneous Ppa/Q relations for both lungs, with Q on the ordinate, were obtained by altering QT via an arteriovenous fistula and an inferior vena cava occluder. Ppa/Q slopes (delta Q/delta Ppa) and extrapolated zero-flow Ppa intercepts (Pzf) were obtained by linear regression analysis. Bilateral PEEP increased Pzf for both lungs (P less than 0.01) but did not alter delta Q/delta Ppa of either lung. Unilateral PEEP decreased ipsilateral blood flow (P less than 0.001) and increased Pzf for the ipsilateral lung (P less than 0.05). Left lung PEEP did not affect the slope of the left lung Ppa/Q relationship (delta QL/delta Ppa). Hypoxic ventilation of the left lung decreased QL (P less than 0.001), increased Pzf (P less than 0.05), and decreased delta QL/delta Ppa (P less than 0.001). Neither uni- nor bilateral PEEP altered this flow diversion away from the left lung or the reduction in delta QL/delta Ppa with left lung hypoxia. We conclude that PEEP and alveolar hypoxia increase pulmonary vascular resistance at different loci, such that their effects are additive. A net increase in 10 cmH2O of PEEP does not inhibit the pulmonary vascular response to regional alveolar hypoxia.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Domino, KB
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Date: September 1990
Date Type: Publication
Journal or Publication Title: Am J Physiol
Volume: 259
Number: 3 Pt 2
Page Range: H697 - H705
DOI or Unique Handle: 10.1152/ajpheart.1990.259.3.h697
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
Uncontrolled Keywords: Animals, Dogs, Hypoxia, Male, Positive-Pressure Respiration, Pulmonary Circulation, Vasoconstriction
ISSN: 0002-9513
PubMed ID: 2204276
Date Deposited: 24 Feb 2012 15:20
Last Modified: 30 Jan 2020 16:56
URI: http://d-scholarship.pitt.edu/id/eprint/11067

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