Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Hemodynamic effects of synchronous high-frequency jet ventilation in mitral regurgitation

Stein, KL and Kramer, DJ and Killian, A and Pinsky, MR (1990) Hemodynamic effects of synchronous high-frequency jet ventilation in mitral regurgitation. Journal of Applied Physiology, 69 (6). 2120 - 2125. ISSN 0161-7567

[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)


We tested the hypothesis that increases in intrathoracic pressure (ITP), by decreasing the pressure gradient for anterograde left ventricular (LV) ejection, should augment cardiac output in acute mitral regurgitation (MR). In a pentobarbital-anesthetized closed-chest canine model, LV stroke volume (SL(LV)) was measured by integration from an aortic flow probe signal. MR was induced by a regurgitant ring. ITP was elevated over apnea by means of intermittent positive-pressure ventilation (IPPV), asynchronous (asynch) high-frequency jet ventilation (HFJV), and cardiac cycle-specific (synch) HFJV. IPPV resulted in the greatest increase in ITP. MR caused a fall in SV(LV) and a rise in LV filling pressure that were not altered by IPPV. Compared with IPPV or apnea, both asynch and synch HFJV increased SV(LV) and reduced LV filling pressures (P < 0.05). Systolic synch HFJV induced a greater increase in SV(LV) (32%) than diastolic synch HFJV (26%) despite similar ventilatory settings. Our data suggest that when LV contractility is normal but MR impairs forward flow, cardiac cycle-specific increases in ITP will augment forward flow.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Stein, KL
Kramer, DJ
Killian, A
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Date: 1 January 1990
Date Type: Publication
Journal or Publication Title: Journal of Applied Physiology
Volume: 69
Number: 6
Page Range: 2120 - 2125
DOI or Unique Handle: 10.1152/jappl.1990.69.6.2120
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 0161-7567
PubMed ID: 2077009
Date Deposited: 24 Feb 2012 15:21
Last Modified: 06 Jul 2020 13:55


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item