Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Flow redistribution during progressive hemorrhage is a determinant of critical O<inf>2</inf> delivery

Schlichtig, R and Kramer, DJ and Pinsky, MR (1991) Flow redistribution during progressive hemorrhage is a determinant of critical O<inf>2</inf> delivery. Journal of Applied Physiology, 70 (1). 169 - 178. ISSN 0161-7567

[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)

Abstract

O2 consumption (V̇O2) of anesthetized whole mammals is independent of O2 delivery (ḊO2) until ḊO2 declines to a critical value (ḊO(2c)). Below this value, V̇O2 becomes O2 supply dependent. We assessed the influence of whole body ḊO2 redistribution among organs with respect to the commencement of O2 supply dependency. We measured ḊO2, V̇O2, and ḊO(2c) of whole body, liver, intestine, kidney, and remaining carcass in eight mongrel dogs during graded progressive hemorrhage. Whole body ḊO2 was redistributed such that the organ-to-whole body ḊO2 ratio declined for liver and kidney and increased for carcass. We then created a mathematical model wherein each organ-to-whole body ḊO2 ratio remained approximately constant at all values of whole body ḊO2 and assigned organ V̇O2 to predicted organ ḊO2 by interpolation and extrapolation of observed V̇O2-ḊO2 plots. The model predicted that O2 supply dependency without redistribution would have commenced at a higher value of whole body ḊO2 for whole body (8.11 ± 0.89 vs. 6.98 ± 1.16 ml·kg-1·min-1, P < 0.05) and carcass (6.83 ± 1.16 vs. 5.06 ± 1.15 ml·kg-1·min-1, P < 0.01 ) and at a lower value of whole body ḊO2 for liver (6.33 ± 1.86 vs. 7.59 ± 1.95, ml·kg-1·min-1, P < 0.02) and kidney (1.25 ± 0.64 vs. 4.54 ± 1.29 ml·kg-1·min-1, P < 0.01). We conclude that redistribution of whole body ḊO2 among organs facilitates whole body O2 regulation.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Schlichtig, R
Kramer, DJ
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Date: 1 January 1991
Date Type: Publication
Journal or Publication Title: Journal of Applied Physiology
Volume: 70
Number: 1
Page Range: 169 - 178
DOI or Unique Handle: 10.1152/jappl.1991.70.1.169
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 0161-7567
PubMed ID: 2010373
Date Deposited: 24 Feb 2012 15:23
Last Modified: 25 May 2020 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/11078

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com


Actions (login required)

View Item View Item