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Interleukin-6 administration has no acute hemodynamic or hematologic effect in the dog

Preiser, JC and Schmartz, D and Van der Linden, P and Content, J and Vanden Bussche, P and Buurman, W and Sebald, W and Dupont, E and Pinsky, MR and Vincent, JL (1991) Interleukin-6 administration has no acute hemodynamic or hematologic effect in the dog. Cytokine, 3 (1). 1 - 4. ISSN 1043-4666

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Abstract

To investigate the possible hemodynamic effects of interleukin-6 (IL-6), a single dose of 15 mcg/kg of recombinant IL-6 isolated from Escherichia coli was injected intravenously in six pentobarbital-anesthetized dogs. After 30 min, saline infusion was performed to maintain the pulmonary artery balloon-occluded pressure at baseline level. The animals were observed for up to 5 hours. No other hemodynamic alteration was observed than a gradual decline in cardiac output attributed to anesthesia. Hematologic variables, blood glucose, and total serum proteins were also constant. IL-6 levels were markedly elevated in the blood, but no tumor necrosis factor activity was detected. Thus a primary role for IL-6 in the early cardiovascular alterations associated with septic shock seems unlikely. © 1991.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Preiser, JC
Schmartz, D
Van der Linden, P
Content, J
Vanden Bussche, P
Buurman, W
Sebald, W
Dupont, E
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Vincent, JL
Date: 1 January 1991
Date Type: Publication
Journal or Publication Title: Cytokine
Volume: 3
Number: 1
Page Range: 1 - 4
DOI or Unique Handle: 10.1016/1043-4666(91)90002-u
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 1043-4666
PubMed ID: 1883951
Date Deposited: 24 Feb 2012 15:25
Last Modified: 30 Jan 2020 16:56
URI: http://d-scholarship.pitt.edu/id/eprint/11085

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