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Renal O<inf>2</inf> consumption during progressive hemorrhage

Schlichtig, R and Kramer, DJ and Boston, JR and Pinsky, MR (1991) Renal O<inf>2</inf> consumption during progressive hemorrhage. Journal of Applied Physiology, 70 (5). 1957 - 1962. ISSN 0161-7567

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Abstract

Most mammalian tissues regulate O2 utilization such that O2 consumption (V̇O2) is relatively constant at O2 delivery (ḊO2) higher than a critical value (ḊO(2 c)). We studied the relationship between V̇O2 and ḊO2 of kidney and whole body during graded progressive exsanguination. The relationship between whole body V̇O2 and ḊO2 was biphasic, and whole body V̇O2 decreased by 5.6 ± 14.4% (P = NS) from the initial value to the value nearest whole body ḊO(2 c). Kidney ḊO2 decreased in direct proportion to whole body ḊO2 such that the average R2 value describing the linear regression of kidney ḊO2 vs. whole body ḊO2 was 0.94 ± 0.02. The relationship between kidney, like whole body, V̇O2 and ḊO2 appeared biphasic; however, kidney V̇O2 decreased by 63.3 ± 10.4% (P < 0.0001) from the initial value to the value nearest kidney ḊO(2 c). Renal O2 extraction ratio was relatively constant over a wide range of kidney ḊO2, whereas whole body O2 extraction ratio increased progressively at all whole body ḊO2 values as whole body ḊO2 decreased. However, final values of O2 extraction ratio were indistinguishable for whole body (0.86 ± 0.1) and kidney (0.86 ± 0.06) (P = NS). We conclude that the pattern of kidney and whole body V̇O2 response to decreasing ḊO2 differs during hemorrhage, particularly in the range of ḊO2 normally associated with tissue wellness.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Schlichtig, R
Kramer, DJ
Boston, JR
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Date: 1 January 1991
Date Type: Publication
Journal or Publication Title: Journal of Applied Physiology
Volume: 70
Number: 5
Page Range: 1957 - 1962
DOI or Unique Handle: 10.1152/jappl.1991.70.5.1957
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 0161-7567
PubMed ID: 1864775
Date Deposited: 24 Feb 2012 15:26
Last Modified: 06 Jul 2020 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/11087

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