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Continuous monitoring of right ventricular volume changes using a conductance catheter in the rabbit

Solda, PL and Pantaleo, P and Perlini, S and Calciati, A and Finardi, G and Pinsky, MR and Bernardi, L (1992) Continuous monitoring of right ventricular volume changes using a conductance catheter in the rabbit. Journal of Applied Physiology, 73 (5). 1770 - 1775. ISSN 0161-7567

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Abstract

To assess the reliability of conductance (G) catheter for evaluating right ventricular (RV) volume changes, a miniature (3.5F) six-electrode catheter was developed and tested in 11 New Zealand rabbit hearts. In five animals the heart was excised; in six it was left in the thorax RV conductance was recorded while the RV was filled with blood in 0.25-ml steps at different left ventricular (LV) volumes. Linear correlation of measured conductance vs. reference volumes was computed. RV conductance was highly correlated with reference volume [correlation coefficient (r) ranging from 0.991 to 0.999]. Slope of regression lines was not significantly affected by LV volume variations in 1-ml steps or by acute conductance changes of structures surrounding the heart, whereas the intercept was affected only by the 0- to 1-ml LV volume change. In four rabbits, RV conductance changes during a cardiac cycle [stroke volume- (SV) G] were compared in vivo with electromagnetic flow probe-derived estimates of SV (SVem) as stroke volume was varied by graded inferior vena caval occlusion. SV-G correlated well with SVem (r ranging from 0.92 to 0.96). This correlation persisted after the thorax was filled with saline; however, significant differences were found in individual slopes (P < 0.001). These results show that the conductance catheter has a potential to reliably monitor in vivo relative RV volume changes in small-animal hearts.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Solda, PL
Pantaleo, P
Perlini, S
Calciati, A
Finardi, G
Pinsky, MRpinsky@pitt.eduPINSKY
Bernardi, L
Date: 1 January 1992
Date Type: Publication
Journal or Publication Title: Journal of Applied Physiology
Volume: 73
Number: 5
Page Range: 1770 - 1775
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 0161-7567
PubMed ID: 1474050
Date Deposited: 01 Mar 2012 20:11
Last Modified: 04 Feb 2019 15:57
URI: http://d-scholarship.pitt.edu/id/eprint/11113

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