Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Effect of the pericardium on systolic ventricular interdependence in the dog

Schertz, C and Pinsky, MR (1993) Effect of the pericardium on systolic ventricular interdependence in the dog. Journal of Critical Care, 8 (1). 17 - 23. ISSN 0883-9441

[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)


Systolic ventricular interdependence, whereby changes in left ventricular (LV) ejection alter right ventricular (RV) ejection, has been described. It is unclear, however, whether this interaction is influenced by pericardial volume constraint or by myocardial mechanical coupling. We hypothesized that if mechanical coupling were the primary factor determining systolic ventricular interdependence then it should be unaltered by the presence or absence of an intact pericardium, but affected by changes in LV end-systolic volume. We tested this hypothesis by observing the changes in RV stroke volume (SVrv) and peak systolic pressure (PSPrv) during a single LV isovolumic contraction under conditions of normal or increased (1.3 × normal) RV end-diastolic volume with and without an intact pericardium. In 10 anesthetized, open-chested dogs SVrv was derived from the integrated pulmonary arterial flow probe signal and RV ejection fraction (EFrv) was derived from the thermodilution plateau method and a rapidly responsive thermistor in the pulmonary artery. Right ventricular end-diastolic volume was considered to be the ratio of SVrv to EFrv. Left ventricular isovolumic contraction increased SVrv and PSPrv during all conditions P <.01). However, PSPrv increased more when the pericardium was intact (P <.05). These data suggest that LV ejection can enhance SVrv and that this interaction is not appreciably altered by volume loading or the presence of an intact pericardium. Pericardial interactions may alter PSPrv but do not affect SVrv. © 1993.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Schertz, C
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Date: 1 January 1993
Date Type: Publication
Journal or Publication Title: Journal of Critical Care
Volume: 8
Number: 1
Page Range: 17 - 23
DOI or Unique Handle: 10.1016/0883-9441(93)90029-k
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 0883-9441
PubMed ID: 8343855
Date Deposited: 01 Mar 2012 20:13
Last Modified: 22 Jun 2021 14:55


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item