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Inhaled nitric oxide partially reverses hypoxic pulmonary vasoconstriction in the dog

Romand, JA and Pinsky, MR and Firestone, L and Zar, HA and Lancaster, JR (1994) Inhaled nitric oxide partially reverses hypoxic pulmonary vasoconstriction in the dog. Journal of Applied Physiology, 76 (3). 1350 - 1355. ISSN 8750-7587

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Nitric oxide (NO) inhaled during a hypoxia-induced increase in pulmonary vasomotor tone decreases pulmonary arterial pressure (Ppa). We conducted this study to better characterize the hemodynamic effects induced by NO inhalation during hypoxic pulmonary vasoconstriction in 11 anesthetized ventilated dogs. Arterial and venous systemic and pulmonary pressures and aortic flow probe- derived cardiac output were recorded, and nitrosylhemoglobin (NO-Hb) and methemoglobin (MetHb) were measured. The effects of 5 min of NO inhalation at 0, 17, 28, 47, and 0 ppm during hyperoxia (inspiratory fraction of O2 = 0.5) and hypoxia (inspiratory fraction of O2 = 0.16) were observed. NO inhalation has no measurable effects during hyperoxia. Hypoxia induced an increase in Ppa that reached plateau levels after 5 min. Exposure to 28 and 47 ppm NO induced an immediate (<30 s) decrease in Ppa and calculated pulmonary vascular resistance (P < 0.05 each) but did not return either to baseline hyperoxic values. Increasing the concentration of NO to 74 and 145 ppm in two dogs during hypoxia did not induce any further decreases in Ppa. Reversing hypoxia while NO remained at 47 ppm further decreased Ppa and pulmonary vascular resistance to baseline values. NO inhalation did not induce decreases in systemic arterial pressure. MetHb remained low, and NO-Hb was unmeasurable. We concluded that NO inhalation only partially reversed hypoxia-induced increases in pulmonary vasomotor tone in this canine model. These effects are immediate and selective to the pulmonary circulation.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Romand, JA
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Firestone, L
Zar, HA
Lancaster, JR
Date: 1 January 1994
Date Type: Publication
Journal or Publication Title: Journal of Applied Physiology
Volume: 76
Number: 3
Page Range: 1350 - 1355
DOI or Unique Handle: 10.1152/jappl.1994.76.3.1350
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 8750-7587
Related URLs:
PubMed ID: 8005882
Date Deposited: 01 Mar 2012 20:34
Last Modified: 22 Jun 2021 14:55


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