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The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination.

Bernard, GR and Artigas, A and Brigham, KL and Carlet, J and Falke, K and Hudson, L and Lamy, M and Legall, JR and Morris, A and Spragg, R (1994) The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med, 149 (3 Pt 1). 818 - 824. ISSN 1073-449X

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Abstract

The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies, carries a high morbidity, mortality (10 to 90%), and financial cost. The reported annual incidence in the United States is 150,000 cases, but this figure has been challenged, and it may be different in Europe. Part of the reason for these uncertainties are the heterogeneity of diseases underlying ARDS and the lack of uniform definitions for ARDS. Thus, those who wish to know the true incidence and outcome of this clinical syndrome are stymied. The American-European Consensus Committee on ARDS was formed to focus on these issues and on the pathophysiologic mechanisms of the process. It was felt that international coordination between North America and Europe in clinical studies of ARDS was becoming increasingly important in order to address the recent plethora of potential therapeutic agents for the prevention and treatment of ARDS.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Bernard, GR
Artigas, A
Brigham, KL
Carlet, J
Falke, K
Hudson, L
Lamy, M
Legall, JR
Morris, A
Spragg, R
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
Committee MemberPinsky, Michael Rpinsky@pitt.eduPINSKYUNSPECIFIED
Date: March 1994
Date Type: Publication
Journal or Publication Title: Am J Respir Crit Care Med
Volume: 149
Number: 3 Pt 1
Page Range: 818 - 824
DOI or Unique Handle: 10.1164/ajrccm.149.3.7509706
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
Uncontrolled Keywords: Americas, Clinical Protocols, Clinical Trials as Topic, Europe, Humans, Incidence, Oxygen Inhalation Therapy, Prevalence, Prognosis, Radiography, Respiratory Distress Syndrome, Risk Factors
ISSN: 1073-449X
Funders: NHLBI NIH HHS (NHLBI HL19153), NHLBI NIH HHS (NHLBI HL43167)
PubMed ID: 7509706
Date Deposited: 05 Mar 2012 17:52
Last Modified: 19 Dec 2020 23:55
URI: http://d-scholarship.pitt.edu/id/eprint/11179

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