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Hepatic anion flux during acute endotoxemia

Kellum, JA and Bellomo, R and Kramer, DJ and Pinsky, MR (1995) Hepatic anion flux during acute endotoxemia. Journal of Applied Physiology, 78 (6). 2212 - 2217. ISSN 8750-7587

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We sought to determine the role the liver might play in the regulation of anion-cation balance during both stable baseline conditions and acute endotoxemia. Ten pentobarbital sodium-anesthetized dogs were instrumented at laparotomy with ultrasonic flow probes around the left renal artery, portal vein, and hepatic artery, and catheters were inserted into the hepatic vein, portal vein, pulmonary artery, left renal vein, and abdominal aorta. Measurements were obtained from each site at baseline and 30-45 min after the intravenous infusion of endotoxin. The total anion flux across the liver was calculated from the strong-ion difference. At baseline, the liver removed onions from the circulation (-0.34 meq/min). With early endotoxemia, however, the liver switched to the release of anions (0.12 meq/min; P = 0.0046). After endotoxin administration, the gut, which was neutral at baseline, began to take up anions (-0.47 meq/min; P = 0.008). Anion flux across the lung and kidney was unchanged. We conclude that in the dog the liver, which removes anions at baseline, switches to release anions during early endotoxemia and may be a major site of acid production in early sepsis.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Kellum, JAkellum@pitt.eduKELLUM0000-0003-1995-2653
Bellomo, R
Kramer, DJ
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Date: 1 January 1995
Date Type: Publication
Journal or Publication Title: Journal of Applied Physiology
Volume: 78
Number: 6
Page Range: 2212 - 2217
DOI or Unique Handle: 10.1152/jappl.1995.78.6.2212
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 8750-7587
PubMed ID: 7665420
Date Deposited: 05 Mar 2012 17:22
Last Modified: 30 Jan 2020 16:55


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