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Leukocyte Activation in the Peripheral Blood of Patients With Cirrhosis of the Liver and SIRS: Correlation With Serum Interleukin-6 Levels and Organ Dysfunction

Rosenbloom, AJ and Pinsky, MR and Bryant, JL and Shin, A and Tran, T and Whiteside, T (1995) Leukocyte Activation in the Peripheral Blood of Patients With Cirrhosis of the Liver and SIRS: Correlation With Serum Interleukin-6 Levels and Organ Dysfunction. JAMA: The Journal of the American Medical Association, 274 (1). 58 - 65. ISSN 0098-7484

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Leukocyte adhesion plays an important role in inflammation. Adhesion molecules such as CD11b on polymorphonuclear neutrophil leukocytes (PMNs) up-regulate in response to tumor necrosis factor—α, interleukin-8 (IL-8), and other mediators that are involved in systemic inflammatory response syndrome (SIRS). This study examined the behavior of CD11b and other membrane molecules in SIRS in relation to serum cytokines and the severity of illness. Survey study. Liver transplantation intensive care unit at a tertiary care center. A consecutive sample of 22 patients admitted to the liver transplantation intensive care unit for complications related to cirrhosis of the liver in the absence of other disease. Sixteen of the patients developed SIRS and multiple organ dysfunction syndrome with suspected bacterial infections. Seven control subjects were also studied. Modified Goris organ failure score and Acute Physiology and Chronic Health Evaluation II score. Mean serum IL-6 levels, but not IL-1 β or tumor necrosis factor—α levels, correlated with organ failure (r=0.79, P<.001). Leukocyte cell-surface markers fluctuated from day to day. The mean of several values was more stable. Mean CD11b and CD35 on PMNs correlated with serum IL-6 level (r=0.75, P<.001, and r=0.77, P<.005, respectively). Up-regulation of both CD11b and CD35 display on PMNs correlated with organ failure (r=0.74, P<.001, and r=0.71, P<.01, respectively). Polymorphonuclear neutrophil leukocyte L-selectin, CD31, and CD16 were simultaneously decreased, consistent with PMN activation. Monocytes appeared to be activated, but the pattern of surface molecule display was different. In human SIRS, the circulating monocyte and PMN pools undergo alterations suggestive of leukocyte activation, including up-regulation of PMN CD11b in correlation with the serum IL-6 level and severity of organ dysfunction. (JAMA. 1995;274:58-65). © 1995, JAMA, All rights reserved.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Rosenbloom, AJ
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Bryant, JL
Shin, A
Tran, T
Whiteside, T
Date: 1 January 1995
Date Type: Publication
Journal or Publication Title: JAMA: The Journal of the American Medical Association
Volume: 274
Number: 1
Page Range: 58 - 65
DOI or Unique Handle: 10.1001/jama.1995.03530010072037
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 0098-7484
PubMed ID: 7540697
Date Deposited: 05 Mar 2012 17:22
Last Modified: 30 Jan 2020 16:56


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