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Organ-specific therapy in critical illness: Interfacing molecular mechanisms with physiological interventions

Pinsky, MR (1996) Organ-specific therapy in critical illness: Interfacing molecular mechanisms with physiological interventions. Journal of Critical Care, 11 (2). 95 - 107. ISSN 0883-9441

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Abstract

Sepsis and SIRS is the outward manifestation of a generalized uncontrolled inflammatory response, which, if sustained, induces widespread endothelial damage and MODS. Immunomodulating therapies, at present, have proven ineffective in reducing morbidity and mortality, presumably because of the heterogeneous nature of sepsis and septic shock and the reciprocating and redundant nature of this inflammatory cascade. Organ-specific therapies can support life but impair both organ-specific function and remote organ function. Novel therapies aimed at minimizing further organ dysfunction may improve outcome in a cost-effective fashion by preventing both further primary organ dysfunction or remote organ dysfunction secondary to the subsequent activation of the inflammatory response.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Pinsky, MRpinsky@pitt.eduPINSKY
Date: 1 January 1996
Date Type: Publication
Journal or Publication Title: Journal of Critical Care
Volume: 11
Number: 2
Page Range: 95 - 107
DOI or Unique Handle: 10.1016/s0883-9441(96)90024-6
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 0883-9441
Article Type: Review
PubMed ID: 8727030
Date Deposited: 05 Mar 2012 19:53
Last Modified: 04 Feb 2019 15:56
URI: http://d-scholarship.pitt.edu/id/eprint/11232

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