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Assessment of venous return curve and mean systemic filling pressure in postoperative cardiac surgery patients

Maas, JJ and Geerts, BF and Van Den Berg, PCM and Pinsky, MR and Jansen, JRC (2009) Assessment of venous return curve and mean systemic filling pressure in postoperative cardiac surgery patients. Critical Care Medicine, 37 (3). 912 - 918. ISSN 0090-3493

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OBJECTIVE:: To measure the relationship between blood flow and central venous pressure (Pcv) and to estimate mean systemic filling pressure (Pmsf), circulatory compliance, and stressed volume in patients in the intensive care unit. DESIGN:: Intervention study. SETTING:: Intensive care unit of a university hospital. PATIENTS:: Twelve mechanically ventilated postoperative cardiac surgery patients. INTERVENTIONS:: Inspiratory holds were performed during normovolemia in supine position (baseline), relative hypovolemia by placing the patients in 30 degree head-up position (hypo), and relative hypervolemia by volume loading with 0.5 L colloid (hyper). MEASUREMENTS AND MAIN RESULTS:: We measured the relationship between blood flow and Pcv using 12-second inspiratory-hold maneuvers transiently increasing Pcv to three different steady-state levels and monitored the resultant blood flow via the pulse contour method during the last 3 seconds. The Pcv to blood flow relation was linear for all measurements with a slope unaltered by relative volume status. Pmsf decreased with hypo and increased with hyper (18.8 ± 4.5 mm Hg, to 14.5 ± 3.0 mm Hg, to 29.1 ± 5.2 mm Hg [baseline, hypo, hyper, respectively, p < 0.05]). Baseline total circulatory compliance was 0.98 mL•mm Hg•kg and stressed volume was 1677 mL. CONCLUSIONS:: Pmsf can be determined in intensive care patients with an intact circulation with use of inspiratory pause procedures, making serial measures of circulatory compliance and circulatory stressed volume feasible. © 2009 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Maas, JJ
Geerts, BF
Van Den Berg, PCM
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Jansen, JRC
Date: 1 January 2009
Date Type: Publication
Journal or Publication Title: Critical Care Medicine
Volume: 37
Number: 3
Page Range: 912 - 918
DOI or Unique Handle: 10.1097/ccm.0b013e3181961481
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 0090-3493
PubMed ID: 19237896
Date Deposited: 07 Mar 2012 20:11
Last Modified: 30 Jan 2020 16:55


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