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Is there occult tissue ischemia in chronic end-stage liver disease?

Parker, BM and Dishart, MK and Pinsky, MR and Kang, Y (1999) Is there occult tissue ischemia in chronic end-stage liver disease? Liver Transplantation and Surgery, 5 (3). 211 - 218. ISSN 1074-3022

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Whether pathological oxygen supply dependency exists in patients with chronic end-stage liver disease (CESLD) is unknown, although the frequently occurring multiorgan dysfunction seen in these patients may be the result of occult tissue ischemia. In this study, 15 adult patients with CESLD were evaluated for the presence of pathological oxygen supply dependency and, thus, occult tissue ischemia before undergoing orthotopic liver transplantation. Whole-body oxygen consumption (Vo2) was measured using indirect calorimetry at baseline, at reduced oxygen delivery (Do2) using positive end-expiratory pressure, and at increased Do2 using volume infusion. As a group, no significant increase or decrease in Vo2 was observed with changes in Do2. However, 4 patients showed increases in Vo2 of 14%, 10.8%, 9.6%, and 8.2% when Do2 was increased. The study results suggest that pathological oxygen supply dependency is present in a subset of patients with CESLD, and the existence of occult tissue ischemia is speculated.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Parker, BM
Dishart, MK
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Kang, Y
Date: 1 January 1999
Date Type: Publication
Journal or Publication Title: Liver Transplantation and Surgery
Volume: 5
Number: 3
Page Range: 211 - 218
DOI or Unique Handle: 10.1002/lt.500050305
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 1074-3022
PubMed ID: 10226113
Date Deposited: 20 Mar 2012 15:42
Last Modified: 22 Jun 2021 14:55


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