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Suppression of cytokine-mediated β<inf>2</inf>-integrin activation on circulating neutrophils in critically ill patients

Rosenbloom, AJ and Pinsky, MR and Napolitano, C and Nguyen, TS and Levann, D and Pencosky, N and Dorrance, A and Ray, BK and Whiteside, T (1999) Suppression of cytokine-mediated β<inf>2</inf>-integrin activation on circulating neutrophils in critically ill patients. Journal of Leukocyte Biology, 66 (1). 83 - 89. ISSN 0741-5400

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The β2 integrin CD11b plays a central role in inflammation and the systemic inflammatory response syndrome (SIRS). The CD11b molecule activates in two ways: the density of membrane-bound CD11b up-regulates and the molecule undergoes a conformational change that confers adhesiveness to counter-receptors. We studied the kinetics of CD11b activation in patients with SIRS. We found a significantly diminished CD11b activation in response to tumor necrosis factor α (TNF-α). This affected all circulating polymorphonuclear neutrophils (PMN) and was an intrinsic property of the cells and not due to antagonism by soluble TNF-α receptors or loss of cellular receptors for TNF-α. Diminished responsiveness correlated with the severity of organ failure and lasted for months in some patients but had no impact on mortality. We speculate that reduced CD11b responsiveness in SIRS contributes to the high risk of recurrent infection, but that it may also be protective against excessive PMN activation within the vascular space.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Rosenbloom, AJ
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Napolitano, C
Nguyen, TS
Levann, D
Pencosky, N
Dorrance, A
Ray, BK
Whiteside, T
Date: 1 January 1999
Date Type: Publication
Journal or Publication Title: Journal of Leukocyte Biology
Volume: 66
Number: 1
Page Range: 83 - 89
DOI or Unique Handle: 10.1002/jlb.66.1.83
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 0741-5400
PubMed ID: 10410993
Date Deposited: 22 Mar 2012 20:50
Last Modified: 22 Jun 2021 16:55


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