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Cardiac contractility is not depressed in early canine endotoxic shock.

Pinsky, MR and Rico, P (2000) Cardiac contractility is not depressed in early canine endotoxic shock. Am J Respir Crit Care Med, 161 (4 Pt 1). 1087 - 1093. ISSN 1073-449X

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We investigated effects of acute endotoxemia (Escherichia coli endotoxin, 1 mg/kg, intravenously) on left ventricular (LV) function in the first 4 h after induction of endotoxic shock in anesthetized canine preparations (n = 7 each, endotoxin and control groups). LV pressure and conductance (volume) catheters were used to construct pressure-volume loops. Transient inferior vena cava occlusion was used to rapidly and reversibly alter LV end-diastolic volume. LV contractility was assessed from the slope of the LV end-systolic pressure-volume relationship (Ees) and from preload-recruitable stroke work (PRSW), and from their change (DeltaEes and DeltaPRSW, respectively, measured at 2 and 4 h only), in response to a dobutamine infusion (5 microg/kg/min). Diastolic function and arterial tone were assessed as the maximal negative change in filling pressure versus time (max -dP/dt), filling rate, and arterial elastance (Ea), respectively. Ees, PRSW, Ea, diastolic function, and hemodynamics were measured hourly. Endotoxemia induced an immediate hypotensive, hyperdynamic, tachycardic state with progressive lactic acidosis. By 2.5 h after endotoxin infusion, heart rate returned to preendotoxin and control levels, but the other changes remained. However, no change occurred in LV Ees, DeltaEes, PRSW, DeltaPRSW, diastolic function, or Ea during the 4-h measurement interval. The cardiovascular collapse seen during the first 4 h of endotoxemia is therefore not due even partly to alterations in LV contractility.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Rico, P
Date: April 2000
Date Type: Publication
Journal or Publication Title: Am J Respir Crit Care Med
Volume: 161
Number: 4 Pt 1
Page Range: 1087 - 1093
DOI or Unique Handle: 10.1164/ajrccm.161.4.9904033
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
Uncontrolled Keywords: Animals, Cardiac Catheterization, Dogs, Endotoxemia, Escherichia coli Infections, Heart Rate, Male, Myocardial Contraction, Shock, Septic, Stroke Volume, Time Factors, Ventricular Function, Left
ISSN: 1073-449X
PubMed ID: 10764295
Date Deposited: 22 Mar 2012 20:41
Last Modified: 30 Jan 2020 16:56


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