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Immune balance in critically ill patients

Pinsky, MR (2000) Immune balance in critically ill patients. Archivum Immunologiae et Therapiae Experimentalis, 48 (6). 439 - 442. ISSN 0004-069X

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The systemic inflammatory response reflects the non-specific clinical expression of a profound activation of the body's immune responsive elements. Immune activation and immune suppression coexist in the blood of patients with severe sepsis. It is their interaction and the resultant host parenchymal responses that ultimately define the course of sepsis. Importantly, neither profound immune activation (pro-inflammatory) or immune suppression (anti-inflammatory) characterize the dominant process. Rather, there is a combined low grade pro-inflammatory state associated with an immune hyporesponsiveness that defines the usual immunologic state of the patient with severe sepsis.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Date: 1 December 2000
Date Type: Publication
Journal or Publication Title: Archivum Immunologiae et Therapiae Experimentalis
Volume: 48
Number: 6
Page Range: 439 - 442
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 0004-069X
Article Type: Review
PubMed ID: 11197596
Date Deposited: 22 Mar 2012 20:54
Last Modified: 30 Jan 2020 16:56


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