Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Dynamic effects of positive-pressure ventilation on canine left ventricular pressure-volume relations

Denault, AY and Gorcsan, J and Pinsky, MR (2001) Dynamic effects of positive-pressure ventilation on canine left ventricular pressure-volume relations. Journal of Applied Physiology, 91 (1). 298 - 308. ISSN 8750-7587

[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)

Abstract

Positive-pressure ventilation (PPV) may affect left ventricular (LV) performance by altering both LV diastolic compliance and pericardial pressure (Ppc). We measured the effect of PPV on LV intraluminal pressure, Ppc, LV volume, and LV cross-sectional area in 17 acute anesthetized dogs. To account for changes in lung volume independent of changes in Ppc and differences in contractility, measures were made during both open- and closed-chest conditions, during closed chest with and without chest wall binding, and after propranolol-induced acute ventricular failure (AVF). Apneic end-systolic pressure-volume relations (ESPVR) were generated by inferior vena caval occlusions. With the open chest, PPV had no effects. With the chest closed, PPV inspiration decreased LV end-diastolic volume (EDV) along its diastolic compliance curve and decreased end-systolic volume (ESV) such that the end-systolic pressure-volume domain was shifted to a point left of the LV ESPVR, even when referenced to Ppc. The decrease in EDV was greater in control than in AVF conditions, whereas the shift of the ESV to the left of the ESPVR was greater with AVF than in control conditions. We conclude that the hemodynamic effects of PPV inspiration are due primarily to changes in intrathoracic pressure and that the inspiration-induced decreases of LV EDV reflect direct effects of intrathoracic pressure on LV filling. The decreases in LV ESV exceed the amount explained solely by a reduction in LV ejection pressure.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Denault, AY
Gorcsan, Jgorcsan@pitt.eduGORCSAN
Pinsky, MRpinsky@pitt.eduPINSKY
Date: 5 July 2001
Date Type: Publication
Journal or Publication Title: Journal of Applied Physiology
Volume: 91
Number: 1
Page Range: 298 - 308
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 8750-7587
PubMed ID: 11408444
Date Deposited: 20 Mar 2012 16:08
Last Modified: 04 Feb 2019 15:56
URI: http://d-scholarship.pitt.edu/id/eprint/11460

Metrics

Monthly Views for the past 3 years

Plum Analytics


Actions (login required)

View Item View Item