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Quality-adjusted survival in the first year after the acute respiratory distress syndrome

Angus, DC and Musthafa, AA and Clermont, G and Griffin, MF and Linde-Zwirble, WT and Dremsizov, TT and Pinsky, MR (2001) Quality-adjusted survival in the first year after the acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine, 163 (6). 1389 - 1394. ISSN 1073-449X

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There is little information on long-term outcome after acute respiratory distress syndrome (ARDS). We measured quality-adjusted survival in the first year after ARDS in a prospective cohort (n = 200). All patients met traditional criteria for ARDS. Patients with sepsis and acute nonpulmonary organ dysfunction at presentation were excluded. The cohort was healthy before onset of ARDS as evidenced by high functional status (mean Karnofsky Performance Status index: 82.2/100 where ≥ 80 = able to perform normal activities independently) and minimal comorbid illness (mean Charlson-Deyo comorbidity score: 0.32/17 where 0 = absence of chronic illness). We determined quality-adjusted life-years (QALYs) using the Quality of Well-being (QWB) scale (0 to 1 scale where 1 = optimal well-being), measured at 6 and 12 mo. Survival was 69.5 ± 5.0% at 1 month, fell to 55.7 ± 3.7% at 6 mo, and did not change at 12 mo, yielding a survival of 59 life-years in the first year per 100 patients with ARDS. QWB was low at 6 and 12 mo (0.59 ± 0.015 and 0.60 ± 0.015), yielding a quality-adjusted survival of 36 QALYs per 100 patients (sensitivity range: 21 to 46 QALYs). We conclude that ARDS developing in previously healthy patients is associated with poor quality-adjusted survival. These data are important for cost-effectiveness analyses and long-term care.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Angus, DCangusdc@pitt.eduANGUSDC0000-0002-7026-5181
Musthafa, AA
Clermont, Gcler@pitt.eduCLER0000-0002-0163-1379
Griffin, MF
Linde-Zwirble, WT
Dremsizov, TT
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Date: 1 January 2001
Date Type: Publication
Journal or Publication Title: American Journal of Respiratory and Critical Care Medicine
Volume: 163
Number: 6
Page Range: 1389 - 1394
DOI or Unique Handle: 10.1164/ajrccm.163.6.2005123
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 1073-449X
PubMed ID: 11371406
Date Deposited: 20 Mar 2012 15:57
Last Modified: 14 Feb 2021 01:55


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