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Nitric oxide contamination of hospital compressed air improves gas exchange in patients with acute lung injury

Tan, SP and Genc, F and Delgado, E and Kellum, J and Pinsky, M (2002) Nitric oxide contamination of hospital compressed air improves gas exchange in patients with acute lung injury. Intensive Care Medicine, 28 (8). 1064 - 1072. ISSN 0342-4642

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Objective: We tested the hypothesis that NO contamination of hospital compressed air also improves PaO2 in patients with acute lung injury (ALI) and following lung transplant (LTx). Design: Prospective clinical study. Setting: Cardiothoracic intensive care unit. Patients: Subjects following cardiac surgery (CABG, n=7); With ALI (n=7), and following LTx (n=5). Interventions: Four sequential 15-min steps at a constant FiO2 were used: hospital compressed air-O2 (H1), N2-O2 (A1), repeat compressed air-O2 (H2), and repeat N2-O2 (A2). Measurements and results: NO levels were measured from the endotracheal tube. Cardiorespiratory values included PaO2 were measured at the end of each step. FiO2 was 0.46±0.05, 0.53±0.15, and 0.47±0.06 (mean±SD) for three groups, respectively. Inhaled NO levels during H1 varied among subjects (30-550 ppb, 27-300 ppb, and 5-220 ppb, respectively). Exhaled NO levels were not detected in 4/7 of CABG (0-300 ppb), 3/6 of ALI (0-140 ppb), and 3/5 of LTx (0-59 ppb) patients during H1, whereas during A1 all but one patient in ALI and three CABG patients had measurable exhaled NO levels (P<0.05). Small but significant decreases in PaO2 occurred for all groups from H1 to A1 and H2 to A2 (132-99 Torr and 128-120 Torr, P <0.01, respectively). There was no correlation between inhaled NO during H1 and exhaled NO during A1 or the change in PaO2 from H1 to A1. Conclusions: Low-level NO contamination improves PaO2 in patients with ALI and following LTx.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Tan, SP
Genc, F
Delgado, E
Kellum, Jkellum@pitt.eduKELLUM0000-0003-1995-2653
Pinsky, Mpinsky@pitt.eduPINSKY0000-0001-6166-700X
Date: 17 September 2002
Date Type: Publication
Journal or Publication Title: Intensive Care Medicine
Volume: 28
Number: 8
Page Range: 1064 - 1072
DOI or Unique Handle: 10.1007/s00134-002-1366-7
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 0342-4642
PubMed ID: 12185426
Date Deposited: 22 Mar 2012 19:47
Last Modified: 22 Jun 2021 14:55


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