Effect of tracheal gas insufflation during weaning from prolonged mechanical ventilation: A preliminary study

Hoffman, LA and Tasota, FJ and Delgado, E and Zullo, TG and Pinsky, MR (2003) Effect of tracheal gas insufflation during weaning from prolonged mechanical ventilation: A preliminary study. American Journal of Critical Care, 12 (1). 31 - 39. ISSN 1062-3264

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Abstract

• BACKGROUND: Tracheal gas insufflation reduces inspired tidal volume and minute ventilation in spontaneously breathing patients and may facilitate weaning from mechanical ventilation. • OBJECTIVE: To determine if tracheal gas insufflation can reduce ventilatory demand during weaning trials in patients who require prolonged mechanical ventilation. • METHODS: A reduction in ventilatory demand was defined as a relative decrease in tidal volume, minute ventilation, and mean inspiratory flow during trials with tracheal gas insufflation compared with the values during trials without this therapy. A total of 14 subjects underwent T-piece trials with and without insufflation (flow rate 6 L/min) on 2 consecutive days; the order of insufflation was randomized. Tidal volume, minute ventilation, and mean inspiratory flow were measured at baseline (without insufflation) and 2 hours later. • RESULTS: Differences in ventilatory demand were not significant when comparisons were made for condition (tracheal gas insufflation vs no flow) or time (baseline vs 2 hours) for the total group (P=.48). Subjects were classified post hoc as responders (n=9) or nonresponders (n=5). Comparisons between responders and nonresponders indicated a significant (P=.02) 3-way multivariate interaction for group (responder vs nonresponder), condition (tracheal gas insufflation vs no flow), and time (baseline vs 2 hours) for ventilatory demand variables. • CONCLUSION: Tracheal gas insufflation can reduce ventilatory demand during weaning trials in some patients who require mechanical ventilation.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Hoffman, LA lhof@pitt.edu LHOF Tasota, FJ Delgado, E Zullo, TG zullo@pitt.edu ZULLO Pinsky, MR pinsky@pitt.edu PINSKY
Date:	1 January 2003
Date Type:	Publication
Journal or Publication Title:	American Journal of Critical Care
Volume:	12
Number:	1
Page Range:	31 - 39
Schools and Programs:	School of Medicine > Critical Care Medicine
Refereed:	Yes
ISSN:	1062-3264
PubMed ID:	12526235
Date Deposited:	22 Mar 2012 19:45
Last Modified:	03 Feb 2019 06:55
URI:	http://d-scholarship.pitt.edu/id/eprint/11523

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