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Effect of tracheal gas insufflation during weaning from prolonged mechanical ventilation: A preliminary study

Hoffman, LA and Tasota, FJ and Delgado, E and Zullo, TG and Pinsky, MR (2003) Effect of tracheal gas insufflation during weaning from prolonged mechanical ventilation: A preliminary study. American Journal of Critical Care, 12 (1). 31 - 39. ISSN 1062-3264

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Abstract

• BACKGROUND: Tracheal gas insufflation reduces inspired tidal volume and minute ventilation in spontaneously breathing patients and may facilitate weaning from mechanical ventilation. • OBJECTIVE: To determine if tracheal gas insufflation can reduce ventilatory demand during weaning trials in patients who require prolonged mechanical ventilation. • METHODS: A reduction in ventilatory demand was defined as a relative decrease in tidal volume, minute ventilation, and mean inspiratory flow during trials with tracheal gas insufflation compared with the values during trials without this therapy. A total of 14 subjects underwent T-piece trials with and without insufflation (flow rate 6 L/min) on 2 consecutive days; the order of insufflation was randomized. Tidal volume, minute ventilation, and mean inspiratory flow were measured at baseline (without insufflation) and 2 hours later. • RESULTS: Differences in ventilatory demand were not significant when comparisons were made for condition (tracheal gas insufflation vs no flow) or time (baseline vs 2 hours) for the total group (P=.48). Subjects were classified post hoc as responders (n=9) or nonresponders (n=5). Comparisons between responders and nonresponders indicated a significant (P=.02) 3-way multivariate interaction for group (responder vs nonresponder), condition (tracheal gas insufflation vs no flow), and time (baseline vs 2 hours) for ventilatory demand variables. • CONCLUSION: Tracheal gas insufflation can reduce ventilatory demand during weaning trials in some patients who require mechanical ventilation.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Hoffman, LAlhof@pitt.eduLHOF
Tasota, FJ
Delgado, E
Zullo, TGzullo@pitt.eduZULLO
Pinsky, MRpinsky@pitt.eduPINSKY
Date: 1 January 2003
Date Type: Publication
Journal or Publication Title: American Journal of Critical Care
Volume: 12
Number: 1
Page Range: 31 - 39
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 1062-3264
PubMed ID: 12526235
Date Deposited: 22 Mar 2012 19:45
Last Modified: 03 Feb 2019 06:55
URI: http://d-scholarship.pitt.edu/id/eprint/11523

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