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Genetic testing: costs and access to intensive care unit care.

Pinsky, Michael R (2003) Genetic testing: costs and access to intensive care unit care. Crit Care Med, 31 (5 Supp). S411 - S415. ISSN 0090-3493

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Critically ill patients require significant medical care and use limited healthcare resources. Furthermore, the mortality rate from most forms of critical illness is much higher than for noncritically ill hospitalized patients. Although genetic diseases increase mortality, most are easily identified at birth and have only limited treatments and prognoses. Recently, more subtle single nucleotide polymorphisms at key loci have been demonstrated to result in a profoundly different prevalences of acute illness and subsequent survival rates for subjects with apparently similar insults and otherwise similar phenotypes. With the maturation of the human genome project, this new discovery will allow for the characterization of individual subject's responsiveness and potential for recovery from a number of insults. This realization makes our definition of genetic diseases blurred and begs the questions, "Will these new insights allow for more effective healthcare resource utilization, as defined from patient, healthcare system, and societal perspectives?" and, perhaps more worrisome, "Should intensive care resources be limited to those with the greatest chance of benefit?" Similarly, as with other genetic predispositions such as cystic fibrosis and congenital hypercholesterolemia, to what extent should these data be available outside the patient-doctor relationship?


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Pinsky, Michael Rpinsky@pitt.eduPINSKY0000-0001-6166-700X
Date: May 2003
Date Type: Publication
Journal or Publication Title: Crit Care Med
Volume: 31
Number: 5 Supp
Page Range: S411 - S415
DOI or Unique Handle: 10.1097/01.ccm.0000065277.22601.f6
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
Uncontrolled Keywords: Critical Care, Critical Illness, Genetic Predisposition to Disease, Genetic Privacy, Genetic Testing, Health Care Rationing, Humans, Polymorphism, Single Nucleotide, Sepsis, United States
ISSN: 0090-3493
Funders: NHLBI NIH HHS (K-24 HL67181-01A1)
PubMed ID: 12771593
Date Deposited: 22 Mar 2012 19:39
Last Modified: 28 Jan 2023 19:55


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