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Passive leg raising predicts fluid responsiveness in the critically ill

Monnet, X and Rienzo, M and Osman, D and Anguel, N and Richard, C and Pinsky, MR and Teboul, JL (2006) Passive leg raising predicts fluid responsiveness in the critically ill. Critical Care Medicine, 34 (5). 1402 - 1407. ISSN 0090-3493

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Objective: Passive leg raising (PLR) represents a "self-volume challenge" that could predict fluid response and might be useful when the respiratory variation of stroke volume cannot be used for that purpose. We hypothesized that the hemodynamic response to PLR predicts fluid responsiveness in mechanically ventilated patients. Design: Prospective study. Setting: Medical intensive care unit of a university hospital. Patients: We investigated 71 mechanically ventilated patients considered for volume expansion. Thirty-one patients had spontaneous breathing activity and/or arrhythmias. Interventions: We assessed hemodynamic status at baseline, after PLR, and after volume expansion (500 mL NaCl 0.9% infusion over 10 mins). Measurements and Main Results: We recorded aortic blood flow using esophageal Doppler and arterial pulse pressure. We calculated the respiratory variation of pulse pressure in patients without arrhythmias. In 37 patients (responders), aortic blood flow increased by ≥15% after fluid infusion. A PLR increase of aortic blood flow ≥10% predicted fluid responsiveness with a sensitivity of 97% and a specificity of 94%. A PLR increase of pulse pressure a 12% predicted volume responsiveness with significantly lower sensitivity (60%) and specificity (85%). In 30 patients without arrhythmias or spontaneous breathing, a respiratory variation in pulse pressure ≥12% was of similar predictive value as was PLR increases in aortic blood flow (sensitivity of 88% and specificity of 93%). In patients with spontaneous breathing activity, the specificity of respiratory variations in pulse pressure was poor (46%). Conclusions: The changes in aortic blood flow induced by PLR predict preload responsiveness in ventilated patients, whereas with arrhythmias and spontaneous breathing activity, respiratory variations of arterial pulse pressure poorly predict preload responsiveness. Copyright © 2006 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Monnet, X
Rienzo, M
Osman, D
Anguel, N
Richard, C
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Teboul, JL
Date: 1 May 2006
Date Type: Publication
Journal or Publication Title: Critical Care Medicine
Volume: 34
Number: 5
Page Range: 1402 - 1407
DOI or Unique Handle: 10.1097/01.ccm.0000215453.11735.06
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 0090-3493
PubMed ID: 16540963
Date Deposited: 05 Apr 2012 21:36
Last Modified: 30 Jan 2020 16:56


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