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Multiple systems organ failure: Failure of host defense homeostasis

Pinsky, MR and Matuschak, GM (1989) Multiple systems organ failure: Failure of host defense homeostasis. Critical Care Clinics, 5 (2). 199 - 220. ISSN 0749-0704

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To understand the processes involved in the development of MSOF, we will first define what is meant by the terms sepsis, shock, MSOF, malignant intravascular inflammation, proinflammatory mediator, and immunocompromised host. We will then briefly discuss manifestations of single organ system failure as they relate to the expression of MSOF, offering as we do, hypotheses with regard to the basic mechanisms of MSOF. Finally, because infection and host response to it appear to be central in the development of MSOF, we will discuss the pathophysiology of septic shock.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Matuschak, GM
Date: 1 January 1989
Date Type: Publication
Journal or Publication Title: Critical Care Clinics
Volume: 5
Number: 2
Page Range: 199 - 220
DOI or Unique Handle: 10.1016/s0749-0704(18)30432-9
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 0749-0704
Article Type: Review
PubMed ID: 2650814
Date Deposited: 12 Jul 2012 21:47
Last Modified: 06 Jul 2020 13:55


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