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Regional oxygen delivery in oxygen supply-dependent states

Pinsky, MR and Schlichtig, R (1990) Regional oxygen delivery in oxygen supply-dependent states. Intensive Care Medicine, 16 (2 Supp). ISSN 0342-4642

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Assessment of the adequacy of systemic O2 delivery (DO2) is central in the evaluation of critically ill patients, but estimates of systemic DO2 do not assess the effectiveness of regional DO2 to all vascular beds whose functions may require different degrees of blood flow depending on their metabolic and functional demands. The oxygen supply-consumption curve includes a supply-in-dependent portion, which represents the reserve capacity of the body to maintain oxygen consumption (VO2) despite inadequate increases in DO2, and a supply-dependent portion, which represents the physiologic adaptation that occurs once DO2 is unable to meet the metabolic demands of the body. Experiments in dogs revealed that when systemic DO2 was progressively reduced, blood flow was maintained in the vital organs (heart and brain) and redistributed away from the kidneys and liver, enhancing the ability of the whole organism to use oxygen efficiently. Disease states and iatrogenic conditions that alter this vasoregulatory process may directly impair organ system function. © 1990 Springer-Verlag.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Schlichtig, R
Date: 1 February 1990
Date Type: Publication
Journal or Publication Title: Intensive Care Medicine
Volume: 16
Number: 2 Supp
DOI or Unique Handle: 10.1007/bf01785248
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 0342-4642
PubMed ID: 2289984
Date Deposited: 12 Jul 2012 21:28
Last Modified: 02 Nov 2021 10:55


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