Pinsky, MR
(2004)
Dysregulation of the immune response in severe sepsis.
American Journal of the Medical Sciences, 328 (4).
220 - 229.
ISSN 0002-9629
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Abstract
Sepsis is systemic expression of a generalized activation of the host's innate immunity as a result of varied types of insults. This expression involves a cellular inflammatory response that has both proinflammatory and antiinflammatory components, the primary trigger for which is an intracellular oxidative stress, induced by receptor-mediated transmembrane signal transduction or direct noxious injury. Sepsis reflects the interaction between pro- and anti-inflammatory intracellular mechanisms, the uncontrolled activation of which leads to cell exhaustion, organ dysfunction, and death. Successful clinical trials of novel treatments for the management of severe sepsis share a common ability to down-regulate this overall response, restoring normal proinflammatory responsiveness and mitochondrial energetic function.
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Details
Item Type: |
Article
|
Status: |
Published |
Creators/Authors: |
|
Date: |
1 January 2004 |
Date Type: |
Publication |
Journal or Publication Title: |
American Journal of the Medical Sciences |
Volume: |
328 |
Number: |
4 |
Page Range: |
220 - 229 |
DOI or Unique Handle: |
10.1097/00000441-200410000-00005 |
Refereed: |
Yes |
ISSN: |
0002-9629 |
PubMed ID: |
15486537 |
Date Deposited: |
14 Jul 2012 20:16 |
Last Modified: |
30 Jan 2020 16:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/12280 |
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