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Dysregulation of the immune response in severe sepsis

Pinsky, MR (2004) Dysregulation of the immune response in severe sepsis. American Journal of the Medical Sciences, 328 (4). 220 - 229. ISSN 0002-9629

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Sepsis is systemic expression of a generalized activation of the host's innate immunity as a result of varied types of insults. This expression involves a cellular inflammatory response that has both proinflammatory and antiinflammatory components, the primary trigger for which is an intracellular oxidative stress, induced by receptor-mediated transmembrane signal transduction or direct noxious injury. Sepsis reflects the interaction between pro- and anti-inflammatory intracellular mechanisms, the uncontrolled activation of which leads to cell exhaustion, organ dysfunction, and death. Successful clinical trials of novel treatments for the management of severe sepsis share a common ability to down-regulate this overall response, restoring normal proinflammatory responsiveness and mitochondrial energetic function.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Date: 1 January 2004
Date Type: Publication
Journal or Publication Title: American Journal of the Medical Sciences
Volume: 328
Number: 4
Page Range: 220 - 229
DOI or Unique Handle: 10.1097/00000441-200410000-00005
Refereed: Yes
ISSN: 0002-9629
PubMed ID: 15486537
Date Deposited: 14 Jul 2012 20:16
Last Modified: 30 Jan 2020 16:55


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