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Normal physiology and pathophysiology of left ventricular systole

Simon, MA and Pinsky, MR (2008) Normal physiology and pathophysiology of left ventricular systole. In: Acute Heart Failure. UNSPECIFIED, 43 - 51. ISBN 9781846287817

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Left ventricular (LV) systole is defined as that part of the cardiac cycle wherein active contraction occurs. Contractile performance is a major determinant of overall cardiac function. The final end-systolic pressure and volume are a function of intrinsic cardiac contractility, myocardial energy state, and ventricular-arterial coupling, whereas the developed stroke volume and stroke work are a function of these factors plus end-diastolic volume. Since end-diastolic volume is a primary determinant of systolic function, through the Frank-Starling mechanism, diastolic dysfunction directly alters systolic performance. Diastolic dysfunction is discussed elsewhere in this volume. In this chapter we focus only on systolic events. © 2008 Springer-Verlag London.


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Item Type: Book Section
Status: Published
CreatorsEmailPitt UsernameORCID
Simon, MA
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Date: 1 December 2008
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Page Range: 43 - 51
DOI or Unique Handle: 10.1007/978-1-84628-782-4_6
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISBN: 9781846287817
Title of Book: Acute Heart Failure
Date Deposited: 28 Jun 2012 15:03
Last Modified: 30 Jan 2020 16:56


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