Simon, MA and Pinsky, MR
(2008)
Normal physiology and pathophysiology of left ventricular systole.
In:
Acute Heart Failure.
UNSPECIFIED, 43 - 51.
ISBN 9781846287817
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Abstract
Left ventricular (LV) systole is defined as that part of the cardiac cycle wherein active contraction occurs. Contractile performance is a major determinant of overall cardiac function. The final end-systolic pressure and volume are a function of intrinsic cardiac contractility, myocardial energy state, and ventricular-arterial coupling, whereas the developed stroke volume and stroke work are a function of these factors plus end-diastolic volume. Since end-diastolic volume is a primary determinant of systolic function, through the Frank-Starling mechanism, diastolic dysfunction directly alters systolic performance. Diastolic dysfunction is discussed elsewhere in this volume. In this chapter we focus only on systolic events. © 2008 Springer-Verlag London.
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