Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Toward a better ventilation strategy for patients with acute lung injury

Pinsky, MR (2000) Toward a better ventilation strategy for patients with acute lung injury. Critical Care, 4 (4). 205 - 206. ISSN 1364-8535

[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)


Ventilator-induced lung injury is a major outcome determinant of the acute respiratory distress syndrome (ARDS). Ventilatory strategies that limit ventilator-induced lung injury should improve outcome from ARDS. The ARDSnet trial showed improved survival in subjects ventilated with a lower tidal volume. Although this trial developed and tested a rigorous clinical protocol, it did not define the limits to which tidal volume reduction would benefit outcome. It is also not at all clear if it is the reduction in tidal volume or the reduction in plateau airway pressure that confers this benefit. Finally, ventilator-induced lung injury occurs more commonly from repetitive collapse and re-expansion of injured lung units rather than from the overdistention of persistently aerated lung units. This was not addressed in the trial design. Thus, further study using targeted open-lung strategies are also needed.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Date: 26 August 2000
Date Type: Publication
Journal or Publication Title: Critical Care
Volume: 4
Number: 4
Page Range: 205 - 206
DOI or Unique Handle: 10.1186/cc695
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 1364-8535
Article Type: Review
PubMed Central ID: PMC150037
PubMed ID: 11094502
Date Deposited: 05 Jul 2012 14:05
Last Modified: 30 Jan 2020 16:55


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item