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Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex

Belov, K and Deakin, JE and Papenfuss, AT and Baker, ML and Melman, SD and Siddle, HV and Gouin, N and Goode, DL and Sargeant, TJ and Robinson, MD and Wakefield, MJ and Mahony, S and Cross, JGR and Benos, PV and Samollow, PB and Speed, TP and Marshall Graves, JA and Miller, RD (2006) Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex. PLoS Biology, 4 (3). 0317 - 0328. ISSN 1545-7885

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Abstract

The first sequenced marsupial genome promises to reveal unparalleled insights into mammalian evolution. We have used the Monodelphis domestica (gray short-tailed opossum) sequence to construct the first map of a marsupial major histocompatibility complex (MHC). The MHC is the most gene-dense region of the mammalian genome and is critical to immunity and reproductive success. The marsupial MHC bridges the phylogenetic gap between the complex MHC of eutherian mammals and the minimal essential MHC of birds. Here we show that the opossum MHC is gene dense and complex, as in humans, but shares more organizational features with non-mammals. The Class I genes have amplified within the Class II region, resulting in a unique Class I/II region. We present a model of the organization of the MHC in ancestral mammals and its elaboration during mammalian evolution. The opossum genome, together with other extant genomes, reveals the existence of an ancestral "immune supercomplex" that contained genes of both types of natural killer receptors together with antigen processing genes and MHC genes. Copyright: © 2006 Belov et al.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Belov, K
Deakin, JE
Papenfuss, AT
Baker, ML
Melman, SD
Siddle, HV
Gouin, N
Goode, DL
Sargeant, TJ
Robinson, MD
Wakefield, MJ
Mahony, S
Cross, JGR
Benos, PVbenos@pitt.eduBENOS
Samollow, PB
Speed, TP
Marshall Graves, JA
Miller, RD
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorPloegh, Hidde L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 1 March 2006
Date Type: Publication
Journal or Publication Title: PLoS Biology
Volume: 4
Number: 3
Page Range: 0317 - 0328
DOI or Unique Handle: 10.1371/journal.pbio.0040046
Schools and Programs: Graduate School of Public Health > Human Genetics
Refereed: Yes
ISSN: 1545-7885
PubMed ID: 16435885
Date Deposited: 11 Jul 2012 18:03
Last Modified: 31 Jul 2020 17:02
URI: http://d-scholarship.pitt.edu/id/eprint/12845

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