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ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia.

Maldarelli, F and Palmer, S and King, MS and Wiegand, A and Polis, MA and Mican, J and Kovacs, JA and Davey, RT and Rock-Kress, D and Dewar, R and Liu, S and Metcalf, JA and Rehm, C and Brun, SC and Hanna, GJ and Kempf, DJ and Coffin, JM and Mellors, JW (2007) ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia. PLoS pathogens, 3 (4).

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Abstract

Current antiretroviral therapy is effective in suppressing but not eliminating HIV-1 infection. Understanding the source of viral persistence is essential for developing strategies to eradicate HIV-1 infection. We therefore investigated the level of plasma HIV-1 RNA in patients with viremia suppressed to less than 50-75 copies/ml on standard protease inhibitor- or non-nucleoside reverse transcriptase inhibitor-containing antiretroviral therapy using a new, real-time PCR-based assay for HIV-1 RNA with a limit of detection of one copy of HIV-1 RNA. Single copy assay results revealed that > 80% of patients on initial antiretroviral therapy for 60 wk had persistent viremia of one copy/ml or more with an overall median of 3.1 copies/ml. The level of viremia correlated with pretherapy plasma HIV-1 RNA but not with the specific treatment regimen. Longitudinal studies revealed no significant decline in the level of viremia between 60 and 110 wk of suppressive antiretroviral therapy. These data suggest that the persistent viremia on current antiretroviral therapy is derived, at least in part, from long-lived cells that are infected prior to initiation of therapy.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Maldarelli, F
Palmer, S
King, MS
Wiegand, A
Polis, MA
Mican, J
Kovacs, JA
Davey, RT
Rock-Kress, D
Dewar, R
Liu, S
Metcalf, JA
Rehm, C
Brun, SC
Hanna, GJ
Kempf, DJ
Coffin, JM
Mellors, JWjwm1@pitt.eduJWM1
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorMalim, Michael H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 1 April 2007
Date Type: Publication
Journal or Publication Title: PLoS pathogens
Volume: 3
Number: 4
DOI or Unique Handle: 10.1371/journal.ppat.0030046
Refereed: Yes
PubMed ID: 17411338
Date Deposited: 11 Jul 2012 17:43
Last Modified: 05 Feb 2018 14:55
URI: http://d-scholarship.pitt.edu/id/eprint/12863

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