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Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration

Vandenbroucke, JP and Von Elm, E and Altman, DG and Gøtzsche, PC and Mulrow, CD and Pocock, SJ and Poole, C and Schlesselman, JJ and Egger, M (2007) Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration. PLoS Medicine, 4 (10). 1628 - 1654. ISSN 1549-1277

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Much medical research is observational. The reporting of observational studies is often of insufficient quality. Poor reporting hampers the assessment of the strengths and weaknesses of a study and the generalisability of its results. Taking into account empirical evidence and theoretical considerations, a group of methodologists, researchers, and editors developed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) recommendations to improve the quality of reporting of observational studies. The STROBE Statement consists of a checklist of 22 items, which relate to the title, abstract, introduction, methods, results and discussion sections of articles. Eighteen items are common to cohort studies, casecontrol studies and cross-sectional studies and four are specific to each of the three study designs. The STROBE Statement provides guidance to authors about how to improve the reporting of observational studies and facilitates critical appraisal and interpretation of studies by reviewers, journal editors and readers. This explanatory and elaboration document is intended to enhance the use, understanding, and dissemination of the STROBE Statement. The meaning and rationale for each checklist item are presented. For each item, one or several published examples and, where possible, references to relevant empirical studies and methodological literature are provided. Examples of useful flow diagrams are also included. The STROBE Statement, this document, and the associated Web site (http://www. should be helpful resources to improve reporting of observational research. © 2007 Vandenbroucke et al.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Vandenbroucke, JP
Von Elm, E
Altman, DG
Gøtzsche, PC
Mulrow, CD
Pocock, SJ
Poole, C
Schlesselman, JJjjs66@pitt.eduJJS66
Egger, M
Centers: Other Centers, Institutes, Offices, or Units > Pittsburgh Cancer Institute
Date: 1 October 2007
Date Type: Publication
Journal or Publication Title: PLoS Medicine
Volume: 4
Number: 10
Page Range: 1628 - 1654
DOI or Unique Handle: 10.1371/journal.pmed.0040297
Schools and Programs: Graduate School of Public Health > Biostatistics
Refereed: Yes
ISSN: 1549-1277
PubMed ID: 17941715
Date Deposited: 18 Jul 2012 21:06
Last Modified: 02 Feb 2019 14:55


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