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Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918

Nelson, MI and Viboud, C and Simonsen, L and Bennett, RT and Griesemer, SB and St George, K and Taylor, J and Spiro, DJ and Sengamalay, NA and Ghedin, E and Taubenberger, JK and Holmes, EC (2008) Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918. PLoS Pathogens, 4 (2). ISSN 1553-7366

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Abstract

The H1N1 subtype of influenza A virus has caused substantial morbidity and mortality in humans, first documented in the global pandemic of 1918 and continuing to the present day. Despite this disease burden, the evolutionary history of the A/H1N1 virus is not well understood, particularly whether there is a virological basis for several notable epidemics of unusual severity in the 1940s and 1950s. Using a data set of 71 representative complete genome sequences sampled between 1918 and 2006, we show that segmental reassortment has played an important role in the genomic evolution of A/H1N1 since 1918. Specifically, we demonstrate that an A/H1N1 isolate from the 1947 epidemic acquired novel PB2 and HA genes through intra-subtype reassortment, which may explain the abrupt antigenic evolution of this virus. Similarly, the 1951 influenza epidemic may also have been associated with reassortant A/H1N1 viruses. Intra-subtype reassortment therefore appears to be a more important process in the evolution and epidemiology of H1N1 influenza A virus than previously realized.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Nelson, MI
Viboud, C
Simonsen, L
Bennett, RT
Griesemer, SB
St George, K
Taylor, J
Spiro, DJ
Sengamalay, NA
Ghedin, Eelg21@pitt.eduELG21
Taubenberger, JK
Holmes, EC
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorKawaoka, YoshihiroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 1 February 2008
Date Type: Publication
Journal or Publication Title: PLoS Pathogens
Volume: 4
Number: 2
DOI or Unique Handle: 10.1371/journal.ppat.1000012
Schools and Programs: School of Medicine > Computational Biology
School of Medicine > Infectious Diseases and Microbiology
Refereed: Yes
ISSN: 1553-7366
PubMed ID: 18463694
Date Deposited: 18 Jul 2012 20:53
Last Modified: 29 Jan 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/12934

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