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A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury

Li, NYK and Verdolini, K and Clermont, G and Mi, Q and Rubinstein, EN and Hebda, PA and Vodovotz, Y (2008) A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury. PLoS ONE, 3 (7).

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Abstract

The development of personalized medicine is a primary objective of the medical community and increasingly also of funding and registration agencies. Modeling is generally perceived as a key enabling tool to target this goal. Agent-Based Models (ABMs) have previously been used to simulate inflammation at various scales up to the whole-organism level. We extended this approach to the case of a novel, patient-specific ABM that we generated for vocal fold inflammation, with the ultimate goal of identifying individually optimized treatments. ABM simulations reproduced trajectories of inflammatory mediators in laryngeal secretions of individuals subjected to experimental phonotrauma up to 4 hrs post-injury, and predicted the levels of inflammatory mediators 24 hrs post-injury. Subject-specific simulations also predicted different outcomes from behavioral treatment regimens to which subjects had not been exposed. We propose that this translational application of computational modeling could be used to design patient-specific therapies for the larynx, and will serve as a paradigm for future extension to other clinical domains. © 2008 Li et al.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Li, NYK
Verdolini, K
Clermont, Gcler@pitt.eduCLER
Mi, QQi.Mi@pitt.eduQIM3
Rubinstein, EN
Hebda, PA
Vodovotz, Yvodovotz@pitt.eduVODOVOTZ
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorCsete, MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Centers: Other Centers, Institutes, or Units > McGowan Institute for Regenerative Medicine
Date: 30 July 2008
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 3
Number: 7
DOI or Unique Handle: 10.1371/journal.pone.0002789
Schools and Programs: Dietrich School of Arts and Sciences > Communication Science and Disorders
School of Medicine > Critical Care Medicine
Refereed: Yes
PubMed ID: 18665229
Date Deposited: 18 Jul 2012 20:26
Last Modified: 02 Feb 2019 16:58
URI: http://d-scholarship.pitt.edu/id/eprint/12982

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