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Molecular epidemiology of A/H3N2 and A/H1N1 influenza virus during a single epidemic season in the United States

Nelson, MI and Edelman, L and Spiro, DJ and Boyne, AR and Bera, J and Halpin, R and Ghedin, E and Miller, MA and Simonsen, L and Viboud, C and Holmes, EC (2008) Molecular epidemiology of A/H3N2 and A/H1N1 influenza virus during a single epidemic season in the United States. PLoS Pathogens, 4 (8). ISSN 1553-7366

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Abstract

To determine the spatial and temporal dynamics of influenza A virus during a single epidemic, we examined whole-genome sequences of 284 A/H1N1 and 69 A/H3N2 viruses collected across the continental United States during the 2006-2007 influenza season, representing the largest study of its kind undertaken to date. A phylogenetic analysis revealed that multiple clades of both A/H1N1 and A/H3N2 entered and co-circulated in the United States during this season, even in localities that are distant from major metropolitan areas, and with no clear pattern of spatial spread. In addition, co-circulating clades of the same subtype exchanged genome segments through reassortment, producing both a minor clade of A/H3N2 viruses that appears to have re-acquired sensitivity to the adamantane class of antiviral drugs, as well as a likely antigenically distinct A/H1N1 clade that became globally dominant following this season. Overall, the co-circulation of multiple viral clades during the 2006-2007 epidemic season revealed patterns of spatial spread that are far more complex than observed previously, and suggests a major role for both migration and reassortment in shaping the epidemiological dynamics of human influenza A virus.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Nelson, MI
Edelman, L
Spiro, DJ
Boyne, AR
Bera, J
Halpin, R
Ghedin, Eelg21@pitt.eduELG21
Miller, MA
Simonsen, L
Viboud, C
Holmes, EC
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorKawaoka, YoshihiroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 1 August 2008
Date Type: Publication
Journal or Publication Title: PLoS Pathogens
Volume: 4
Number: 8
DOI or Unique Handle: 10.1371/journal.ppat.1000133
Schools and Programs: School of Medicine > Infectious Diseases and Microbiology
Refereed: Yes
ISSN: 1553-7366
PubMed ID: 18725925
Date Deposited: 18 Jul 2012 20:24
Last Modified: 29 Jan 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/12984

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