Nelson, MI and Edelman, L and Spiro, DJ and Boyne, AR and Bera, J and Halpin, R and Ghedin, E and Miller, MA and Simonsen, L and Viboud, C and Holmes, EC
(2008)
Molecular epidemiology of A/H3N2 and A/H1N1 influenza virus during a single epidemic season in the United States.
PLoS Pathogens, 4 (8).
ISSN 1553-7366
Abstract
To determine the spatial and temporal dynamics of influenza A virus during a single epidemic, we examined whole-genome sequences of 284 A/H1N1 and 69 A/H3N2 viruses collected across the continental United States during the 2006-2007 influenza season, representing the largest study of its kind undertaken to date. A phylogenetic analysis revealed that multiple clades of both A/H1N1 and A/H3N2 entered and co-circulated in the United States during this season, even in localities that are distant from major metropolitan areas, and with no clear pattern of spatial spread. In addition, co-circulating clades of the same subtype exchanged genome segments through reassortment, producing both a minor clade of A/H3N2 viruses that appears to have re-acquired sensitivity to the adamantane class of antiviral drugs, as well as a likely antigenically distinct A/H1N1 clade that became globally dominant following this season. Overall, the co-circulation of multiple viral clades during the 2006-2007 epidemic season revealed patterns of spatial spread that are far more complex than observed previously, and suggests a major role for both migration and reassortment in shaping the epidemiological dynamics of human influenza A virus.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
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Nelson, MI | | | | Edelman, L | | | | Spiro, DJ | | | | Boyne, AR | | | | Bera, J | | | | Halpin, R | | | | Ghedin, E | elg21@pitt.edu | ELG21 | | Miller, MA | | | | Simonsen, L | | | | Viboud, C | | | | Holmes, EC | | | |
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Contributors: |
Contribution | Contributors Name | Email | Pitt Username | ORCID  |
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Editor | Kawaoka, Yoshihiro | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED |
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Date: |
1 August 2008 |
Date Type: |
Publication |
Journal or Publication Title: |
PLoS Pathogens |
Volume: |
4 |
Number: |
8 |
DOI or Unique Handle: |
10.1371/journal.ppat.1000133 |
Schools and Programs: |
School of Medicine > Infectious Diseases and Microbiology |
Refereed: |
Yes |
ISSN: |
1553-7366 |
PubMed ID: |
18725925 |
Date Deposited: |
18 Jul 2012 20:24 |
Last Modified: |
29 Jan 2019 15:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/12984 |
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