Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form
D-Scholarship @ Pitt Banner and Links to Homepage

Possible novel therapy for malignant gliomas with secretable trimeric TRAIL

Jeong, M and Kwon, YS and Park, SH and Kim, CY and Jeun, SS and Song, KW and Ko, Y and Robbins, PD and Billiar, TR and Kim, BM and Seol, DW (2009) Possible novel therapy for malignant gliomas with secretable trimeric TRAIL. PLoS ONE, 4 (2).

[img]
Preview
 PDF
Published Version
Available under License : See the attached license file.
Download (3MB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.
Download (1kB)

Abstract

Malignant gliomas are the most common primary brain tumors. Despite intensive clinical investigation and many novel therapeutic approaches, average survival for the patients with malignant gliomas is only about 1 year. Tumor necrosis factor-related apoptosis-inclucing ligand (TRAIL) has shown potent and cancer-selective killing activity and drawn considerable attention as a promising therapy for cancers, but concerns over delivery and toxicity have limited progress. We have developed a secretable trimeric TRAIL (stTRAIL) and here evaluated the therapeutic potential of this stTRAIL-based gene therapy in brain tumors. An adenovirus (Ad-stTRAIL) delivering stTRAIL was injected into intra-cranial human glioma tumors established in nude mice and tumor growth monitored using the magnetic resonance imaging (MRI). Ad-stTRAIL gene therapy showed potent tumor suppressor activity with no toxic side effects at therapeutically effective doses. When compared with 1, 3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a conventional therapy for malignant gliomas, Ad-stTRAIL suppressed tumor growth more potently. The combination of Ad-stTRAIL and BCNU significantly increased survival compared to the control mice or mice receiving Ad-stTRAIL alone. Our data indicate that Ad-stTRAIL, either alone or combined with BCNU, has promise as a novel therapy for malignant gliomas. Copyright: © 2009 Jeong et al.

Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Jeong, M
Kwon, YS
Park, SH
Kim, CY
Jeun, SS
Song, KW
Ko, Y
Robbins, PDprobb@pitt.eduPROBB
Billiar, TRbilliar@pitt.eduBILLIAR
Kim, BM
Seol, DW
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorWu, XiaolinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 20 February 2009
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 4
Number: 2
DOI or Unique Handle: 10.1371/journal.pone.0004545
Refereed: Yes
PubMed Central ID: PMC2641005
PubMed ID: 19229339
Date Deposited: 24 Jul 2012 18:58
Last Modified: 04 Feb 2019 15:57
URI: http://d-scholarship.pitt.edu/id/eprint/13102

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com

Actions (login required)

View Item View Item