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Possible novel therapy for malignant gliomas with secretable trimeric TRAIL

Jeong, M and Kwon, YS and Park, SH and Kim, CY and Jeun, SS and Song, KW and Ko, Y and Robbins, PD and Billiar, TR and Kim, BM and Seol, DW (2009) Possible novel therapy for malignant gliomas with secretable trimeric TRAIL. PLoS ONE, 4 (2).

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Malignant gliomas are the most common primary brain tumors. Despite intensive clinical investigation and many novel therapeutic approaches, average survival for the patients with malignant gliomas is only about 1 year. Tumor necrosis factor-related apoptosis-inclucing ligand (TRAIL) has shown potent and cancer-selective killing activity and drawn considerable attention as a promising therapy for cancers, but concerns over delivery and toxicity have limited progress. We have developed a secretable trimeric TRAIL (stTRAIL) and here evaluated the therapeutic potential of this stTRAIL-based gene therapy in brain tumors. An adenovirus (Ad-stTRAIL) delivering stTRAIL was injected into intra-cranial human glioma tumors established in nude mice and tumor growth monitored using the magnetic resonance imaging (MRI). Ad-stTRAIL gene therapy showed potent tumor suppressor activity with no toxic side effects at therapeutically effective doses. When compared with 1, 3-bis(2-chloroethyl)-1-nitrosourea (BCNU), a conventional therapy for malignant gliomas, Ad-stTRAIL suppressed tumor growth more potently. The combination of Ad-stTRAIL and BCNU significantly increased survival compared to the control mice or mice receiving Ad-stTRAIL alone. Our data indicate that Ad-stTRAIL, either alone or combined with BCNU, has promise as a novel therapy for malignant gliomas. Copyright: © 2009 Jeong et al.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Jeong, M
Kwon, YS
Park, SH
Kim, CY
Jeun, SS
Song, KW
Ko, Y
Robbins, PDprobb@pitt.eduPROBB
Billiar, TRbilliar@pitt.eduBILLIAR
Kim, BM
Seol, DW
ContributionContributors NameEmailPitt UsernameORCID
Date: 20 February 2009
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 4
Number: 2
DOI or Unique Handle: 10.1371/journal.pone.0004545
Refereed: Yes
PubMed Central ID: PMC2641005
PubMed ID: 19229339
Date Deposited: 24 Jul 2012 18:58
Last Modified: 04 Feb 2019 15:57


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