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DRD4 polymorphism moderates the effect of alcohol consumption on social bonding

Creswell, KG and Sayette, MA and Manuck, SB and Ferrell, RE and Hill, SY and Dimoff, JD (2012) DRD4 polymorphism moderates the effect of alcohol consumption on social bonding. PLoS ONE, 7 (2).

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Development of interpersonal relationships is a fundamental human motivation, and behaviors facilitating social bonding are prized. Some individuals experience enhanced reward from alcohol in social contexts and may be at heightened risk for developing and maintaining problematic drinking. We employed a 3 (group beverage condition) ×2 (genotype) design (N = 422) to test the moderating influence of the dopamine D4 receptor gene (DRD4 VNTR) polymorphism on the effects of alcohol on social bonding. A significant gene x environment interaction showed that carriers of at least one copy of the 7-repeat allele reported higher social bonding in the alcohol, relative to placebo or control conditions, whereas alcohol did not affect ratings of 7-absent allele carriers. Carriers of the 7-repeat allele were especially sensitive to alcohol's effects on social bonding. These data converge with other recent gene-environment interaction findings implicating the DRD4 polymorphism in the development of alcohol use disorders, and results suggest a specific pathway by which social factors may increase risk for problematic drinking among 7-repeat carriers. More generally, our findings highlight the potential utility of employing transdisciplinary methods that integrate genetic methodologies, social psychology, and addiction theory to improve theories of alcohol use and abuse. © 2012 Creswell et al.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Creswell, KGkgriffin@pitt.eduKGRIFFIN
Sayette, MAsayette@pitt.eduSAYETTE
Manuck, SBmanuck@pitt.eduMANUCK
Ferrell, RErferrell@pitt.eduRFERRELL
Hill, SYsyh50@pitt.eduSYH50
Dimoff, JDjdd16@pitt.eduJDD16
ContributionContributors NameEmailPitt UsernameORCID
Date: 8 February 2012
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 7
Number: 2
DOI or Unique Handle: 10.1371/journal.pone.0028914
Schools and Programs: Dietrich School of Arts and Sciences > Psychology
Refereed: Yes
Other ID: NLM PMC3275561
PubMed Central ID: PMC3275561
PubMed ID: 22347363
Date Deposited: 03 Aug 2012 15:49
Last Modified: 02 Feb 2019 16:58


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