Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

DRD4 polymorphism moderates the effect of alcohol consumption on social bonding

Creswell, KG and Sayette, MA and Manuck, SB and Ferrell, RE and Hill, SY and Dimoff, JD (2012) DRD4 polymorphism moderates the effect of alcohol consumption on social bonding. PLoS ONE, 7 (2).

[img]
Preview
PDF
Published Version
Available under License : See the attached license file.

Download (167kB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)

Abstract

Development of interpersonal relationships is a fundamental human motivation, and behaviors facilitating social bonding are prized. Some individuals experience enhanced reward from alcohol in social contexts and may be at heightened risk for developing and maintaining problematic drinking. We employed a 3 (group beverage condition) ×2 (genotype) design (N = 422) to test the moderating influence of the dopamine D4 receptor gene (DRD4 VNTR) polymorphism on the effects of alcohol on social bonding. A significant gene x environment interaction showed that carriers of at least one copy of the 7-repeat allele reported higher social bonding in the alcohol, relative to placebo or control conditions, whereas alcohol did not affect ratings of 7-absent allele carriers. Carriers of the 7-repeat allele were especially sensitive to alcohol's effects on social bonding. These data converge with other recent gene-environment interaction findings implicating the DRD4 polymorphism in the development of alcohol use disorders, and results suggest a specific pathway by which social factors may increase risk for problematic drinking among 7-repeat carriers. More generally, our findings highlight the potential utility of employing transdisciplinary methods that integrate genetic methodologies, social psychology, and addiction theory to improve theories of alcohol use and abuse. © 2012 Creswell et al.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Creswell, KGkgriffin@pitt.eduKGRIFFIN
Sayette, MAsayette@pitt.eduSAYETTE
Manuck, SBmanuck@pitt.eduMANUCK
Ferrell, RErferrell@pitt.eduRFERRELL
Hill, SYsyh50@pitt.eduSYH50
Dimoff, JDjdd16@pitt.eduJDD16
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorVerdejo García, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 8 February 2012
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 7
Number: 2
DOI or Unique Handle: 10.1371/journal.pone.0028914
Schools and Programs: Dietrich School of Arts and Sciences > Psychology
Refereed: Yes
Other ID: NLM PMC3275561
PubMed Central ID: PMC3275561
PubMed ID: 22347363
Date Deposited: 03 Aug 2012 15:49
Last Modified: 02 Feb 2019 16:58
URI: http://d-scholarship.pitt.edu/id/eprint/13205

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com


Actions (login required)

View Item View Item