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Complex patterns of human antisera reactivity to novel 2009 H1N1 and historical H1N1 influenza strains

Carter, DM and Lu, HR and Bloom, CE and Crevar, CJ and Cherry, JL and Lipman, DJ and Ross, TM (2012) Complex patterns of human antisera reactivity to novel 2009 H1N1 and historical H1N1 influenza strains. PLoS ONE, 7 (7).

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Abstract

Background: During the 2009 influenza pandemic, individuals over the age of 60 had the lowest incidence of infection with approximately 25% of these people having pre-existing, cross-reactive antibodies to novel 2009 H1N1 influenza isolates. It was proposed that older people had pre-existing antibodies induced by previous 1918-like virus infection(s) that cross-reacted to novel H1N1 strains. Methodology/Principal Findings: Using antisera collected from a cohort of individuals collected before the second wave of novel H1N1 infections, only a minority of individuals with 1918 influenza specific antibodies also demonstrated hemagglutination-inhibition activity against the novel H1N1 influenza. In this study, we examined human antisera collected from individuals that ranged between the ages of 1 month and 90 years to determine the profile of seropositive influenza immunity to viruses representing H1N1 antigenic eras over the past 100 years. Even though HAI titers to novel 2009 H1N1 and the 1918 H1N1 influenza viruses were positively associated, the association was far from perfect, particularly for the older and younger age groups. Conclusions/Significance: Therefore, there may be a complex set of immune responses that are retained in people infected with seasonal H1N1 that can contribute to the reduced rates of H1N1 influenza infection in older populations. © 2012 Carter et al.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Carter, DM
Lu, HR
Bloom, CE
Crevar, CJ
Cherry, JL
Lipman, DJ
Ross, TM
Centers: Other Centers, Institutes, or Units > Center for Vaccine Research
Date: 17 July 2012
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 7
Number: 7
DOI or Unique Handle: 10.1371/journal.pone.0039435
Schools and Programs: School of Medicine > Immunology
School of Medicine > Microbiology and Molecular Genetics
Refereed: Yes
Other ID: NLM PMC3398940
PubMed Central ID: PMC3398940
PubMed ID: 22815705
Date Deposited: 03 Aug 2012 15:59
Last Modified: 02 Feb 2019 16:57
URI: http://d-scholarship.pitt.edu/id/eprint/13245

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