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From re-emergence to hyperendemicity: The natural history of the dengue epidemic in Brazil

Rodriguez-Barraquer, I and Cordeiro, MT and Braga, C and de Souza, WV and Marques, ET and Cummings, DAT (2011) From re-emergence to hyperendemicity: The natural history of the dengue epidemic in Brazil. PLoS Neglected Tropical Diseases, 5 (1).

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Abstract

Background:Dengue virus (DENV) was reintroduced into Brazil in 1986 and by 1995 it had spread throughout the country. In 2007 the number of dengue hemorrhagic fever (DHF) cases more than doubled and a shift in the age distribution was reported. While previously the majority of DHF cases occurred among adults, in 2007 53% of cases occurred in children under 15 years old. The reasons for this shift have not been determined.Methods and Findings:Age stratified cross-sectional seroepidemiologic survey conducted in Recife, Brazil in 2006. Serostatus was determined by ELISA based detection of Dengue IgG. We estimated time-constant and time-varying forces of infection of DENV between 1986 and 2006. We used discrete-time simulation to estimate the accumulation of monotypic and multitypic immunity over time in a population previously completely susceptible to DENV. We projected the age distribution of population immunity to dengue assuming similar hazards of infection in future years. The overall prevalence of DENV IgG was 0.80 (n = 1427). The time-constant force of infection for the period was estimated to be 0.052 (95% CI 0.041, 0.063), corresponding to 5.2% of susceptible individuals becoming infected each year by each serotype. Simulations show that as time since re-emergence of dengue goes by, multitypic immunity accumulates in adults while an increasing proportion of susceptible individuals and those with monotypic immunity are among young age groups. The median age of those monotypically immune can be expected to shift from 24 years, 10 years after introduction, to 13 years, 50 years after introduction. Of those monotypically immune, the proportion under 15 years old shifts from 27% to 58%. These results are consistent with the dengue notification records from the same region since 1995.Interpretation:Assuming that persons who have been monotypically exposed are at highest risk for severe dengue, the shift towards younger patient ages observed in Brazil can be partially explained by the accumulation of multitypic immunity against DENV-1, 2, and 3 in older age groups, 22 years after the re-introduction of these viruses. Serotype specific seroepidemiologic studies are necessary to accurately estimate the serotype specific forces of infection. © 2011 Rodriguez-Barraquer et al.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Rodriguez-Barraquer, I
Cordeiro, MT
Braga, C
de Souza, WV
Marques, ETmarques@pitt.eduMARQUES0000-0003-3826-9358
Cummings, DAT
Date: 15 February 2011
Date Type: Publication
Journal or Publication Title: PLoS Neglected Tropical Diseases
Volume: 5
Number: 1
DOI or Unique Handle: 10.1371/journal.pntd.0000935
Schools and Programs: Graduate School of Public Health > Infectious Diseases and Microbiology
Refereed: Yes
MeSH Headings: Adolescent; Adult; Aged; Aged, 80 and over; Brazil--epidemiology; Child; Child, Preschool; Communicable Diseases, Emerging--epidemiology; Communicable Diseases, Emerging--immunology; Dengue--epidemiology; Dengue--immunology; Dengue Virus--immunology; Endemic Diseases; Female; Humans; Male; Middle Aged; Young Adult
Other ID: NLM PMC3014978
PubMed Central ID: PMC3014978
PubMed ID: 21245922
Date Deposited: 03 Aug 2012 16:00
Last Modified: 30 Mar 2019 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/13250

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