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The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease

Bon, JM and Leader, JK and Weissfeld, JL and Coxson, HO and Zheng, B and Branch, RA and Kondragunta, V and Lee, JS and Zhang, Y and Choi, AMK and Lokshin, AE and Kaminski, N and Gur, D and Sciurba, FC (2009) The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease. PLoS ONE, 4 (8).

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Background: Chronic obstructive pulmonary disease (COPD) is characterized by both airway remodeling and parenchymal destruction. The identification of unique biomarker patterns associated with airway dominant versus parenchymal dominant patterns would support the existence of unique phenotypes representing independent biologic processes. A cross-sectional study was performed to examine the association of serum biomarkers with radiographic airway and parenchymal phenotypes of COPD. Methodology/Principal Findings: Serum from 234 subjects enrolled in a CT screening cohort was analyzed for 33 cytokines and growth factors using a multiplex protein array. The association of serum markers with forced expiratory volume in one second percent predicted (FEV1%) and quantitative CT measurements of airway thickening and emphysema was assessed with and without stratification for current smoking status. Significant associations were found with several serum inflammatory proteins and measurements of FEV1%, airway thickening, and parenchymal emphysema independent of smoking status. The association of select analytes with airway thickening and emphysema was independent of FEV1%. Furthermore, the relationship between other inflammatory markers and measurements of physiologic obstruction or airway thickening was dependent on current smoking status. Conclusions/Significance: Airway and parenchymal phenotypes of COPD are associated with unique systemic serum biomarker profiles. Serum biomarker patterns may provide a more precise classification of the COPD syndrome, provide insights into disease pathogenesis and identify targets for novel patient-specific biological therapies. © 2009 Bon et al.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Bon, JM
Leader, JKjklst3@pitt.eduJKLST3
Weissfeld, JL
Coxson, HO
Zheng, B
Branch, RArab13@pitt.eduRAB13
Kondragunta, V
Lee, JSjsl26@pitt.eduJSL26
Zhang, Yzhang3@pitt.eduZHANG3
Choi, AMK
Lokshin, AElokshina@pitt.eduLOKSHINA
Kaminski, N
Gur, Dgur@pitt.eduGUR
Sciurba, FCfcs@pitt.eduFCS
ContributionContributors NameEmailPitt UsernameORCID
Centers: Other Centers, Institutes, Offices, or Units > Pittsburgh Cancer Institute
Date: 31 August 2009
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 4
Number: 8
DOI or Unique Handle: 10.1371/journal.pone.0006865
Schools and Programs: Graduate School of Public Health > Epidemiology
School of Medicine > Critical Care Medicine
Refereed: Yes
MeSH Headings: Aged; Biological Markers--blood; Cohort Studies; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Pulmonary Disease, Chronic Obstructive--blood; Pulmonary Disease, Chronic Obstructive--physiopathology; Pulmonary Disease, Chronic Obstructive--radiography; Smoking--blood; Tomography, X-Ray Computed
Other ID: NLM PMC2730536
PubMed Central ID: PMC2730536
PubMed ID: 19718453
Date Deposited: 03 Aug 2012 16:20
Last Modified: 02 Feb 2019 21:55


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