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Helminth genomics: The implications for human health

Brindley, PJ and Mitreva, M and Ghedin, E and Lustigman, S (2009) Helminth genomics: The implications for human health. PLoS Neglected Tropical Diseases, 3 (10).

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More than two billion people (one-third of humanity) are infected with parasitic roundworms or flatworms, collectively known as helminth parasites. These infections cause diseases that are responsible for enormous levels of morbidity and mortality, delays in the physical development of children, loss of productivity among the workforce, and maintenance of poverty. Genomes of the major helminth species that affect humans, and many others of agricultural and veterinary significance, are now the subject of intensive genome sequencing and annotation. Draft genome sequences of the filarial worm Brugia malayi and two of the human schistosomes, Schistosoma japonicum and S. mansoni, are now available, among others. These genome data will provide the basis for a comprehensive understanding of the molecular mechanisms involved in helminth nutrition and metabolism, host-dependent development and maturation, immune evasion, and evolution. They are likely also to predict new potential vaccine candidates and drug targets. In this review, we present an overview of these efforts and emphasize the potential impact and importance of these new findings. © 2009 Brindley et al.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Brindley, PJ
Mitreva, M
Ghedin, Eelg21@pitt.eduELG21
Lustigman, S
ContributionContributors NameEmailPitt UsernameORCID
Date: 1 October 2009
Date Type: Publication
Journal or Publication Title: PLoS Neglected Tropical Diseases
Volume: 3
Number: 10
DOI or Unique Handle: 10.1371/journal.pntd.0000538
Schools and Programs: School of Public Health > Infectious Diseases and Microbiology
Refereed: Yes
Article Type: Review
MeSH Headings: Animals; Genome, Helminth; Genomics; Helminthiasis--immunology; Helminthiasis--parasitology; Helminths--classification; Helminths--genetics; Helminths--immunology; Host-Parasite Interactions; Humans; Phylogeny
Other ID: NLM PMC2757907
PubMed Central ID: PMC2757907
PubMed ID: 19855829
Date Deposited: 03 Aug 2012 16:33
Last Modified: 29 Jan 2019 15:56


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