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Women have higher protein content of β-oxidation enzymes in skeletal muscle than men

Maher, AC and Akhtar, M and Vockley, J and Tarnopolsky, MA (2010) Women have higher protein content of β-oxidation enzymes in skeletal muscle than men. PLoS ONE, 5 (8).

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It is well recognized that compared with men, women have better ultra-endurance capacity, oxidize more fat during endurance exercise, and are more resistant to fat oxidation defects i.e. diet-induced insulin resistance. Several groups have shown that the mRNA and protein transcribed and translated from genes related to transport of fatty acids into the muscle are greater in women than men; however, the mechanism(s) for the observed sex differences in fat oxidation remains to be determined. Muscle biopsies from the vastus lateralis were obtained from moderately active men (N = 12) and women (N = 11) at rest to examine mRNA and protein content of genes involved in lipid oxidation. Our results show that women have significantly higher protein content for tri-functional protein alpha (TFPα), very long chain acyl-CoA dehydrogenase (VLCAD), and medium chain acyl-CoA dehydrogenase (MCAD) (P<0.05). There was no significant sex difference in the expression of short-chain hydroxyacyl-CoA dehydrogenase (SCHAD), or peroxisome proliferator activated receptor alpha (PPARa), or PPARc, genes potentially involved in the transcriptional regulation of lipid metabolism. In conclusion, women have more protein content of the major enzymes involved in long and medium chain fatty acid oxidation which could account for the observed differences in fat oxidation during exercise. © 2010 Maher et al.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Maher, AC
Akhtar, M
Vockley, Jjerryvockley@pitt.eduGEV10000-0002-8180-6457
Tarnopolsky, MA
ContributionContributors NameEmailPitt UsernameORCID
Date: 15 October 2010
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 5
Number: 8
DOI or Unique Handle: 10.1371/journal.pone.0012025
Schools and Programs: School of Public Health > Human Genetics
Refereed: Yes
MeSH Headings: Acyl-CoA Dehydrogenase--genetics; Acyl-CoA Dehydrogenase--metabolism; Female; Gene Expression Regulation, Enzymologic; Humans; Lipid Metabolism--genetics; Male; Muscle Proteins--metabolism; Muscle, Skeletal--enzymology; Muscle, Skeletal--metabolism; Oxidation-Reduction; PPAR alpha--metabolism; PPAR gamma--metabolism; RNA, Messenger--genetics; RNA, Messenger--metabolism; Sex Characteristics; Young Adult
Other ID: NLM PMC2917369
PubMed Central ID: PMC2917369
PubMed ID: 20700461
Date Deposited: 15 Aug 2012 18:13
Last Modified: 04 Feb 2023 11:55


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