Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression

Hendrickson, SL and Lautenberger, JA and Chinn, LW and Malasky, M and Sezgin, E and Kingsley, LA and Goedert, JJ and Kirk, GD and Gomperts, ED and Buchbinder, SP and Troyer, JL and O'Brien, SJ (2010) Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. PLoS ONE, 5 (9). 1 - 8.

[img]
Preview
PDF
Published Version
Available under License : See the attached license file.

Download (464kB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)

Abstract

Background: The human mitochondrial genome includes only 13 coding genes while nuclear-encoded genes account for 99% of proteins responsible for mitochondrial morphology, redox regulation, and energetics. Mitochondrial pathogenesis occurs in HIV patients and genetically, mitochondrial DNA haplogroups with presumed functional differences have been associated with differential AIDS progression. Methodology/Principal Findings: Here we explore whether single nucleotide polymorphisms (SNPs) within 904 of the estimated 1,500 genes that specify nuclear-encoded mitochondrial proteins (NEMPs) influence AIDS progression among HIV-1 infected patients. We examined NEMPs for association with the rate of AIDS progression using genotypes generated by an Affymetrix 6.0 genotyping array of 1,455 European American patients from five US AIDS cohorts. Successfully genotyped SNPs gave 50% or better haplotype coverage for 679 of known NEMP genes. With a Bonferroni adjustment for the number of genes and tests examined, multiple SNPs within two NEMP genes showed significant association with AIDS progression: acyl-CoA synthetase medium-chain family member 4 (ACSM4) on chromosome 12 and peroxisomal D3,D2-enoyl- CoA isomerase (PECI) on chromosome 6. Conclusions: Our previous studies on mitochondrial DNA showed that European haplogroups with presumed functional differences were associated with AIDS progression and HAART mediated adverse events. The modest influences of nuclearencoded mitochondrial genes found in the current study add support to the idea that mitochondrial function plays a role in AIDS pathogenesis.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Hendrickson, SL
Lautenberger, JA
Chinn, LW
Malasky, M
Sezgin, E
Kingsley, LAkingsley@pitt.eduKINGSLEY
Goedert, JJ
Kirk, GD
Gomperts, ED
Buchbinder, SP
Troyer, JL
O'Brien, SJ
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorBadger, Jonathan H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 29 October 2010
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 5
Number: 9
Page Range: 1 - 8
DOI or Unique Handle: 10.1371/journal.pone.0012862
Schools and Programs: Graduate School of Public Health > Epidemiology
Graduate School of Public Health > Infectious Diseases and Microbiology
Refereed: Yes
MeSH Headings: Acquired Immunodeficiency Syndrome--genetics; Acquired Immunodeficiency Syndrome--metabolism; Acquired Immunodeficiency Syndrome--pathology; Cell Nucleus--genetics; Cell Nucleus--metabolism; Cohort Studies; Disease Progression; European Continental Ancestry Group--genetics; Female; Genetic Variation; Genotype; Humans; Male; Mitochondria--genetics; Mitochondria--metabolism; Polymorphism, Single Nucleotide; Protein Transport
Other ID: NLM PMC2943476
PubMed Central ID: PMC2943476
PubMed ID: 20877624
Date Deposited: 21 Aug 2012 14:16
Last Modified: 02 Feb 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/13552

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com


Actions (login required)

View Item View Item