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Determinants of ventilation during high-frequency jet ventilation

Guntupalli, KK and Pinsky, MR and Marquez, J and Kruger, K and Gandhi, A and Klain, MM (1987) Determinants of ventilation during high-frequency jet ventilation. Journal of Critical Care, 2 (2). 93 - 100. ISSN 0883-9441

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To better define the variables unrelated to ventilator frequency that affect gas transport during high-frequency jet ventilation (HFJV), we performed experiments in anesthetized paralyzed dogs (n = 8). The independent effects of changing driving pressure (300, 200, 150 kPa), catheter used for HFJV delivery (14-gauge and jet port of endotracheal tube), inspiratory time (30%, 50%, and 70%), and injector cannula diameter (12-gauge, 14-gauge, and 16-gauge) on minute volume (VE ), gas exchange, and cardiac output were studied at a ventilatory frequency of 100 min-1. VE increased with increasing driving pressure and inspiratory time. Entrainment decreased with increasing inspiratory time or when HFJV was delivered either via the jet port of the endotracheal tube, or via a jet cannula with distal side holes. Arterial PCO2 varied inversely with VE. Arterial oxygenation increased with hypocarbia, whereas venous admixture and cardiac output were unchanged. Several factors affect the ventilator-delivered and entrained volumes during HFJV, which in turn affect gas exchange. The determinants of gas exchange during HFJV appear to be similar to those described for conventional low-frequency positive-pressure ventilation. © 1987.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Guntupalli, KK
Pinsky, MRpinsky@pitt.eduPINSKY0000-0001-6166-700X
Marquez, J
Kruger, K
Gandhi, A
Klain, MM
Date: 1 January 1987
Date Type: Publication
Journal or Publication Title: Journal of Critical Care
Volume: 2
Number: 2
Page Range: 93 - 100
DOI or Unique Handle: 10.1016/0883-9441(87)90143-2
Schools and Programs: School of Medicine > Critical Care Medicine
Refereed: Yes
ISSN: 0883-9441
Date Deposited: 25 Aug 2012 17:20
Last Modified: 22 Jun 2021 14:55


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